Evidence map›Paper›PMID 36549738›Full record

ArticleBMJ open2022

Comparative efficacy, cognitive effects and acceptability of electroconvulsive therapies for the treatment of depression: protocol for a systematic review and network meta-analysis.

Stevan Nikolin, Kieran Owens, Rohan Francis-Taylor, Anna Chaimani, Donel M Martin, Michael Bull, Harold A Sackeim, Declan M McLoughlin, Pascal Sienaert, Charles H Kellner and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Stevan NikolinDepartment of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia stevan.nikolin@unsw.edu.au.ORCID 0000-0003-4440-9273
Kieran OwensDepartment of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia.
Rohan Francis-TaylorDepartment of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia.
Anna ChaimaniResearch Center of Epidemiology (CRESS-UMR1153), INSERM, INRA, Universite de Paris, Paris, France.
Donel M MartinDepartment of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia.
Michael BullDepartment of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia.
Harold A SackeimDepartment of Psychiatry, Columbia University, New York, New York, USA.
Declan M McLoughlinDepartment of Psychiatry, Trinity College Dublin, Dublin, Ireland.
Pascal SienaertDepartment of Neurosciences, KU Leuven Psychiatric University Hospital KU Leuven, Leuven, Belgium.ORCID 0000-0002-0650-415X
Charles H KellnerDepartment of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina, USA.
Colleen LooDepartment of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThere have been important advances in the use of electroconvulsive therapy (ECT) to treat major depressive episodes. These include variations to the type of stimulus the brain regions stimulated, and the stimulus parameters (eg, stimulus duration/pulse width). Our aim is to investigate ECT types using a network meta-analysis (NMA) approach and report on comparative treatment efficacy, cognitive side effects and acceptability.

methodWe will conduct a systematic review to identify randomised controlled trials that compared two or more ECT protocols to treat depression. This will be done using the following databases: Embase, MEDLINE PubMed, Web of Science, Scopus, PsycINFO, Cochrane CENTRAL and will be supplemented by personal contacts with researchers in the field. All authors will be contacted to provide missing information. Primary outcomes will be symptom severity on a validated continuous clinician-rated scale of depression, cognitive functioning measured using anterograde verbal recall, and acceptability calculated using all-cause drop-outs. Secondary outcomes will include response and remission rates, autobiographical memory following a course of ECT, and anterograde visuospatial recall.Bayesian random effects hierarchical models will compare ECT types. Additional meta-regressions may be conducted to determine the impact of effect modifiers and patient-specific prognostic factors if sufficient data are available. DISCUSSION: This NMA will facilitate clinician decision making and allow more sophisticated selection of ECT type according to the balance of efficacy, cognitive side effects and acceptability. ETHICS: This systematic review and NMA does not require research ethics approval as it will use published aggregate data and will not collect nor disclose individually identifiable participant data. PROSPERO REGISTRATION NUMBER: CRD42022357098.

Indexed as

Electroconvulsive TherapyMajor Depressive DisorderBayes TheoremCognitionDepressionHumansNetwork Meta-Analysis as TopicSystematic Reviews as TopicAdult psychiatryDepression & mood disordersMENTAL HEALTH

Identifiers

PMID36549738
PMCPMC9772645

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.