ArticleBMJ open2022
Pre-eclampsia and cardiovascular risk: a long-term nationwide cohort study on over 120 000 Finnish women.
Article in BMJ open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Recurrent hypertensive disorders of pregnancy and subsequent maternal coronary heart disease, stroke, and all-cause mortality.Pregnancy (Hoboken, N.J.) · 2026Article
- Long-term mortality in women with a history of hypertensive disorders of pregnancy: a systematic review and meta-analysis.EClinicalMedicine · 2026Article
- Article
- New Zealand Electronic Health Data for Cardiovascular Research: A Review.Clinical epidemiology · 2026Review
- Frequent Use of Premenopausal Progestin in Women With Prior Preeclampsia.The Journal of clinical endocrinology and metabolism · 2025Article
- Weight loss before conception: effects on atherogenic apolipoprotein lipid particles and endothelial function during pregnancy.F&S reports · 2025Article
- Preeclampsia and the Long-Term Risk of Developing Neurological Disorders Requiring Hospital Admission.Neuroepidemiology · 2025Article
- Early Mortality, Cardiovascular, and Renal Diseases in Women's Lives Following Hypertensive Disorders of Pregnancy: The Prospective Nationwide Study CONCEPTION.Journal of the American Heart Association · 2024Article
- Association Between Recurrent Preeclampsia and Attendance at the Blood Pressure Monitoring Appointment After Birth.Journal of obstetric, gynecologic, and neonatal nursing : JOGNN · 2024Article
- Prevalence of pre-eclampsia in 265 patients with an intracranial aneurysm, 393 female relatives versus a control cohort: A case-control study.European journal of neurology · 2024Article
- Article
- Vitamin D may alleviate pre-eclampsia by modulating the ferroptosis signalling pathway: A hypothesis based on recent literature.Journal of cellular and molecular medicine · 2023Review
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo investigate the impact of pre-eclampsia on the future cardiovascular risk in Finnish women
designA registry-based nationwide controlled cohort study.
settingWomen hospitalised for pre-eclampsia in 1969-1993 and control women with a history of normotensive pregnancies followed from the pre-eclampsia diagnosis until 2019 for cardiovascular outcomes.
participants31 688 women with and 91 726 control women without a history of pre-eclampsia. PRIMARY OUTCOME MEASURES: Incidences of and deaths from ischaemic heart disease (IHD), myocardial infarction (MI) and stroke.
resultsIn total, 25 813 (81.5%) women had pre-eclampsia without severe features, 4867 (15.4%) had pre-eclampsia with severe features and 1006 (3.2%) women developed eclampsia. Women with a history of pre-eclampsia showed elevated risks for IHD (HR 1.52, 95% CI 1.44 to 1.59), MI (HR 1.66, 95% CI 1.52 to 1.81) and stroke (HR 1.40, 95% CI 1.32 to 1.48). The risks for death from IHD (HR 1.50, 95% CI 1.28 to 1.75), MI (1.63, 95% CI 1.30 to 2.05) and stroke (1.44, 95% CI 1.03 to 2.01) were also elevated. Pre-eclampsia with severe features or eclampsia was accompanied with 15% higher IHD risk, 19% higher MI risk and 26% higher stroke risk than pre-eclampsia without severe features. The highest risk elevations of 30% for IHD, 32% for MI and 30% for stroke were observed in women with recurrent pre-eclampsia (n=4180).
conclusionPre-eclampsia-related significant elevations in CVD risks of Finnish women with inherently high risk for these diseases were of the same magnitude as reported previously from other countries. Thus, women with a history of pre-eclampsia should be screened and treated early for modifiable cardiovascular risk factors.
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