Evidence map›Paper›PMID 36549723›Full record

ArticleBMJ open2022

Why medicines are used differently from prescribed: a protocol for a prospective patient-oriented observational case study to investigate reasons for non-adherence in primary care.

Kirsi Kvarnström, Aleksi Westerholm, Marja Sa Airaksinen, Helena Liira

Registry-linked trialAbstract read
In one paragraph

Article in BMJ open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05167578 (Identifying Reasons for Non-adherence in Patients With Multi-morbidity), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05167578 unknown statusnot on this map

Identifying Reasons for Non-adherence in Patients With Multi-morbidity: A Protocol for Prospective Observational Study in Primary Care

Typeobservational_patient_registrySponsorHelsinki University Central HospitalRan2021 to 2024Enrolled250ConditionsMedication Adherence, Medication Nonadherence, Chronic DiseaseArmsMedication reconciliation
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Kirsi KvarnströmHUS Pharmacy, Helsinki University Hospital, Helsinki, Finland kirsi.kvarnstrom@helsinki.fi.ORCID 0000-0002-3136-5972
Aleksi WesterholmClinical Pharmacy Group, Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland.ORCID 0000-0003-1904-994X
Marja Sa AiraksinenClinical Pharmacy Group, Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland.
Helena LiiraDepartment of Physical and Rehabilitation Medicine, Helsinki University Hospital, Helsinki, Finland.ORCID 0000-0001-6577-3109

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionPatients do not always tell the physician if they have used medicines differently from prescribed. The challenges that patients experience in medication self-management and adherence have been prioritised globally as among the most crucial factors influencing the effectiveness and safety of pharmacotherapies. METHODS AND ANALYSIS: This study protocol presents a new patient-oriented method to investigate reasons for non-adherence using pharmacist-conducted medication reconciliation in a primary care clinic as data collection point. By interviewing, the pharmacist will learn how the patient has been taking the prescribed medicines and whether any non-prescription medicines and food supplements have been used for self-medication. The pharmacist will document the findings of the conversation to the electronic patient record in a structured format. The pharmacist will collect data related to the characteristics of the patients and outpatient clinics, patients' diseases and medications, and medication discrepancies. These data will be analysed for descriptive statistics to identify (1) the number of discrepancies between the physician's prescription orders and the patient's self-reported use of the medicines, (2) what kind of discrepancies there are, (3) which are high-risk medicines in terms of non-adherence and (4) why medicines were taken differently from prescribed; based on the results, (5) a preliminary conceptual model of patient-reported reasons for non-adherence will be constructed. TRIAL REGISTRATION NUMBER: NCT05167578.

Indexed as

Medication AdherenceMedication ReconciliationHumansObservational Studies as TopicPatientsPharmacistsPrimary Health CareProspective StudiesAdverse eventsPRIMARY CAREProtocols & guidelinesQuality in health careRisk management

Identifiers

PMID36549723
PMCPMC9772666

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.