Evidence map›Paper›PMID 36549580›Full record

ArticleBrain, behavior, and immunity2023

GDF15 and its association with cognitive performance over time in a longitudinal study of middle-aged urban adults.

May A Beydoun, Nicole Noren Hooten, Jordan Weiss, Hind A Beydoun, Michael Georgescu, David W Freeman, Michele K Evans, Alan B Zonderman

Abstract read
In one paragraph

Article in Brain, behavior, and immunity, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Observational
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. CSF IL-6, GDF-15, GFAP and NfL levels in early Alzheimer disease: a pilot study.Therapeutic advances in neurological disorders · 2025
    Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

May A BeydounLaboratory of Epidemiology and Population Sciences, NIA/NIH/IRP, Baltimore, MD, USA. Electronic address: baydounm@mail.nih.gov.
Nicole Noren HootenLaboratory of Epidemiology and Population Sciences, NIA/NIH/IRP, Baltimore, MD, USA.
Jordan WeissStanford Center on Longevity, Stanford University, Stanford, CA, USA.
Hind A BeydounDepartment of Research Programs, Fort Belvoir Community Hospital, Fort Belvoir, VA, USA.
Michael GeorgescuLaboratory of Epidemiology and Population Sciences, NIA/NIH/IRP, Baltimore, MD, USA.
David W FreemanLaboratory of Epidemiology and Population Sciences, NIA/NIH/IRP, Baltimore, MD, USA; Department of Oncological Sciences, School of Medicine, University of Utah, Salt Lake City, UT, USA.
Michele K EvansLaboratory of Epidemiology and Population Sciences, NIA/NIH/IRP, Baltimore, MD, USA.
Alan B ZondermanLaboratory of Epidemiology and Population Sciences, NIA/NIH/IRP, Baltimore, MD, USA.

Funding

Healthy Aging Neighborhoods of Diversity Across LifespanZ01AG000513 · NIA · NATIONAL INSTITUTE ON AGING · PI EVANS, MICHELE K · 2001 to 2008
$6.8M
Intramural NIH HHS Z01 AG000513Intramural NIH HHS Z99 AG999999
6 · The paper itself

Abstract

Serum GDF15 levels are correlated with multiple neurodegenerative diseases. Few studies have tested this marker's association with middle-aged cognitive performance over time, and whether race affects this association is unknown. We examined associations of initial serum GDF15 concentrations with longitudinal cognitive performance, spanning domains of global mental status, visual and verbal memory, attention, fluency, and executive function in a sub-sample of adults participating in the Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) study (n = 776, Age

Indexed as

Cognitive DysfunctionExecutive FunctionCognitionCross-Sectional StudiesFemaleGrowth Differentiation Factor 15HumansLongitudinal StudiesMaleMemoryMiddle AgedGDF15 protein, humanGrowth Differentiation Factor 15AgingCognitive declineGDF15Health disparitiesRace

Identifiers

PMID36549580
PMCPMC10026559

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.