Evidence map›Paper›PMID 36549491›Full record

ArticleEnvironmental research2023

A 15-year follow-up study of mortality in a pooled cohort of World Trade Center rescue and recovery workers.

Jiehui Li, Charles B Hall, Janette Yung, Rebecca D Kehm, Rachel Zeig-Owens, Ankura Singh, James E Cone, Robert M Brackbill, Mark R Farfel, Baozhen Qiao and 6 more

Open access · greenAbstract read
In one paragraph

Article in Environmental research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
7.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
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  3. Article
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  5. Article
  6. Review
  7. Article
  8. Article
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  10. Article
  11. The Long-Term Physical-Psychiatric Comorbidities Related to Childhood Exposure to 9/11 Trauma.International journal of environmental research and public health · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 2 countries.

Jiehui LiNew York City Department of Health and Mental Hygiene, World Trade Center Health Registry, 42-09 28th Street, CN-6W, Long Island City, NY, 11101, United States.
Charles B HallAlbert Einstein College of Medicine, Department of Epidemiology and Population Health, 1300 Morris Park Ave, Bronx, NY, 10461, United States.
Janette YungNew York City Department of Health and Mental Hygiene, World Trade Center Health Registry, 42-09 28th Street, CN-6W, Long Island City, NY, 11101, United States.
Rebecca D KehmNew York City Department of Health and Mental Hygiene, World Trade Center Health Registry, 42-09 28th Street, CN-6W, Long Island City, NY, 11101, United States; Department of Epidemiology, Mailman School of Public Health, Columbia University, 722 W 168th St, New York, NY, 10032, United States.
Rachel Zeig-OwensAlbert Einstein College of Medicine, Department of Epidemiology and Population Health, 1300 Morris Park Ave, Bronx, NY, 10461, United States; Fire Department of the City of New York (FDNY), 9 Metrotech Center 5E-63-K, Brooklyn, NY, 11201, United States; Montefiore Medical Center, Department of Medicine, 111 E. 210th St., The Bronx, NY, 10467, United States.
Ankura SinghFire Department of the City of New York (FDNY), 9 Metrotech Center 5E-63-K, Brooklyn, NY, 11201, United States; Montefiore Medical Center, Department of Medicine, 111 E. 210th St., The Bronx, NY, 10467, United States.
James E ConeNew York City Department of Health and Mental Hygiene, World Trade Center Health Registry, 42-09 28th Street, CN-6W, Long Island City, NY, 11101, United States.
Robert M BrackbillNew York City Department of Health and Mental Hygiene, World Trade Center Health Registry, 42-09 28th Street, CN-6W, Long Island City, NY, 11101, United States.
Mark R FarfelNew York City Department of Health and Mental Hygiene, World Trade Center Health Registry, 42-09 28th Street, CN-6W, Long Island City, NY, 11101, United States.
Baozhen QiaoNew York State Department of Health, Bureau of Cancer Epidemiology, 150 Broadway, Albany, NY, 12204, United States.
Maria J SchymuraNew York State Department of Health, Bureau of Cancer Epidemiology, 150 Broadway, Albany, NY, 12204, United States.
Moshe Z ShapiroWTC Health Program General Responder Data Center, Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, One, Gustave L. Levy Place, Mail Stop 1057, New York, NY, 10029, United States.
Christopher R DasaroWTC Health Program General Responder Data Center, Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, One, Gustave L. Levy Place, Mail Stop 1057, New York, NY, 10029, United States.
Andrew C ToddWTC Health Program General Responder Data Center, Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, One, Gustave L. Levy Place, Mail Stop 1057, New York, NY, 10029, United States.
David J PrezantAlbert Einstein College of Medicine, Department of Epidemiology and Population Health, 1300 Morris Park Ave, Bronx, NY, 10461, United States; Fire Department of the City of New York (FDNY), 9 Metrotech Center 5E-63-K, Brooklyn, NY, 11201, United States; Montefiore Medical Center, Department of Medicine, 111 E. 210th St., The Bronx, NY, 10467, United States.
Paolo BoffettaStony Brook University, Stony Brook Cancer Center, Lauterbur Dr., Stony Brook, NY, 11794, United States; University of Bologna, Department of Medical and Surgical Sciences, Via Zamboni, 33, 40126, Bologna, BO, Italy. Electronic address: paolo.boffetta@stonybrookmedicine.edu.
New York City Department of Health and Mental Hygiene · USAlbert Einstein College of Medicine · USIcahn School of Medicine at Mount Sinai · USNew York State Department of Health · USNew York City Fire Department · USZambon (Italy) · IT

Funding

Extension of the World Trade Center RegistryU50OH009739 · OH · NEW YORK CITY HEALTH/MENTAL HYGIENE · PI FARFEL, MARK R · 2009 to 2025
$120.0M
WORD PROCESSORP30CA013330 · NCI · YESHIVA UNIVERSITY · PI Ulrich Steidl · 1985 to 2026
$111.2M
Mortality among WTC rescue and recovery workersU01OH011480 · OH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BOFFETTA, PAOLO, HALL, CHARLES B · 2017 to 2020
$2.4M
Incidence, Latency, and Survival of Cancer Following World Trade Center ExposureU01OH011315 · OH · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI BOFFETTA, PAOLO, HALL, CHARLES B · 2016 to 2018
$1.4M
Incidence, Latency, and Survival of Cancer Following World Trade Center ExposureU01OH011932 · OH · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI HALL, CHARLES B · 2019 to 2019
$1.1M
Detection and Incidence of Thyroid Cancer among Three Cohorts of WTC-Exposed Rescue and Recovery WorkersU01OH011931 · OH · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI ZEIG-OWENS, RACHEL · 2019 to 2019
$555k
Detection and Incidence of Thyroid Cancer among Three Cohorts of WTC-Exposed Rescue and Recovery WorkersU01OH011681 · OH · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI ZEIG-OWENS, RACHEL · 2018 to 2018
$350k
NCI NIH HHS P30 CA013330NIOSH CDC HHS HHSD200200200384CNIOSH CDC HHS HHSD200201139356CNIOSH CDC HHS HHSD200201139377CNIOSH CDC HHS HHSD200201793325CNIOSH CDC HHS U01 OH011315NIOSH CDC HHS U01 OH011480NIOSH CDC HHS U01 OH011681NIOSH CDC HHS U01 OH011931NIOSH CDC HHS U01 OH011932NIOSH CDC HHS U50 OH009739
6 · The paper itself

Abstract

introductionHazardous exposures from the World Trade Center (WTC) terrorist attacks have been linked to increased incidence of adverse health conditions, often associated with increased mortality. We assessed mortality in a pooled cohort of WTC rescue/recovery workers over 15 years of follow-up. MATERIALS AND

methodsWe analyzed mortality through 2016 in a pooled and deduplicated cohort of WTC rescue/recovery workers from three WTC-exposed cohorts (N = 60,631): the Fire Department of the City of New York (FDNY); the WTC Health Registry (WTCHR); and the General Responder Cohort (GRC). Standardized mortality ratios (SMRs) were estimated to assess mortality vs. the US and NY state populations. Multivariable Cox proportional hazards models were used to examine associations of WTC exposures (date of first arrival, working on the WTC debris pile) with mortality risk.

resultsThere were 1912 deaths over 697,943.33 person-years of follow-up. The SMR for all-cause mortality was significantly lower-than-expected, both when using US (SMR 0.43, 95% confidence interval [CI] 0.42-0.45) and NYS (SMR 0.51, 95% CI 0.49-0.53) as reference populations. SMRs were not elevated for any of the 28 major causes of death. Arriving at the WTC site on 9/11-9/17/2001 vs. 9/18/2001-6/30/2002 was associated with 30-50% higher risk of all-cause, heart disease and smoking-related mortality in non-FDNY/non-GRC members. Conversely, arriving on 9/11/2001 vs. 9/18/2001-6/30/2002 was associated with 40% lower all-cause and smoking-related mortality risk in FDNY members. Working on vs. off the WTC pile was associated with an increased risk of all-cause mortality in non-FDNY/non-GRC members (adjusted hazard ratio [aHR] 1.25, 95% CI 1.04-1.50), and cancer-specific mortality in GRC members (aHR 1.39, 95% CI 1.05-1.84), but lower mortality risks were found in FDNY members.

conclusionsWe did not observe excess mortality among WTC rescue/recovery workers compared with general populations. However, significantly increased mortality risks among some sub-groups with high WTC exposure warrant further investigation.

Indexed as

Occupational ExposureSeptember 11 Terrorist AttacksFollow-Up StudiesHumansNew YorkNew York CityRescue WorkRisk9/11Cause of deathMortalityRescue and recovery workersTerrorist attacksWorld Trade Center (WTC)

Identifiers

PMID36549491
PMCPMC12703491
OpenAlexW4311894719

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.