Evidence map›Paper›PMID 36549264›Full record

ArticleClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2023

Central-positive complexes in ECT-induced seizures: Possible evidence for thalamocortical mechanisms.

Emma R Huels, MohammadMehdi Kafashan, L Brian Hickman, ShiNung Ching, Nan Lin, Eric J Lenze, Nuri B Farber, Michael S Avidan, R Edward Hogan, Ben Julian A Palanca

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. How electroconvulsive therapy works in the treatment of depression: is it the seizure, the electricity, or both?Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Review
  4. Movements and central positive complexes during an ECT-induced seizure: A video-EEG case.Epileptic disorders : international epilepsy journal with videotape · 2023
    Article
  5. Electric Field, Ictal Theta Power, and Clinical Outcomes in Electroconvulsive Therapy.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2023
    Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Emma R HuelsDepartment of Anesthesiology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA; Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI, USA; Department of Anesthesiology, University of Michigan, Ann Arbor, MI, USA; Center for Consciousness Science, University of Michigan, Ann Arbor, MI, USA.
MohammadMehdi KafashanDepartment of Anesthesiology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA; Center on Biological Rhythms and Sleep, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.
L Brian HickmanDepartment of Anesthesiology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA; Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
ShiNung ChingDepartment of Electrical & Systems Engineering, Washington University in St. Louis, St. Louis, MO, USA; Division of Biology and Biomedical Sciences, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.
Nan LinDepartment of Mathematics and Statistics, Washington University in St. Louis, St. Louis, MO, USA.
Eric J LenzeDepartment of Psychiatry, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.
Nuri B FarberDepartment of Psychiatry, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.
Michael S AvidanDepartment of Anesthesiology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA; Division of Biology and Biomedical Sciences, Washington University School of Medicine in St. Louis, St. Louis, MO, USA; Department of Psychiatry, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.
R Edward HoganDepartment of Neurology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.
Ben Julian A PalancaDepartment of Anesthesiology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA; Center on Biological Rhythms and Sleep, Washington University School of Medicine in St. Louis, St. Louis, MO, USA; Division of Biology and Biomedical Sciences, Washington University School of Medicine in St. Louis, St. Louis, MO, USA; Department of Psychiatry, Washington University School of Medicine in St. Louis, St. Louis, MO, USA; Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, USA; Neuroimaging Labs Research Center, Washington University School of Medicine in St. Louis, St. Louis, MO, USA. Electronic address: palancab@wustl.edu.
Washington University in St. Louis · US

Funding

PHARMacist and Community Health Support to Optimize Medications After Trauma Surgery (PHARM-C)P50MH122351 · NIMH · WASHINGTON UNIVERSITY · PI Eric J Lenze · 2021 to 2026
$10.8M
Slow Wave Induction by Propofol to Eliminate Depression (SWIPED) TrialU01MH128483 · NIMH · WASHINGTON UNIVERSITY · PI LENZE, ERIC J, PALANCA, BEN JULIAN · 2022 to 2025
$2.8M
Disruptions of Brain Networks and Sleep by Electroconvulsive TherapyK01MH128663 · NIMH · WASHINGTON UNIVERSITY · PI MohammadMehdi Kafashan · 2022 to 2026
$792k
NIMH NIH HHS K01 MH128663NIMH NIH HHS P50 MH122351NIMH NIH HHS U01 MH128483
6 · The paper itself

Abstract

objectiveCentral-positive complexes (CPCs) are elicited during electroconvulsive therapy (ECT) as generalized high-amplitude waveforms with maximum positive voltage over the vertex. While these complexes have been qualitatively assessed in previous literature, quantitative analyses are lacking. This study aims to characterize CPCs across temporal, spatial, and spectral domains.

methodsHigh-density 64-electrode electroencephalogram (EEG) recordings during 50 seizures acquired from 11 patients undergoing right unilateral ECT allowed for evaluation of spatiotemporal characteristics of CPCs via source localization and spectral analysis.

resultsPeak-amplitude CPC scalp topology was consistent across seizures, showing maximal positive polarity over the midline fronto-central region and maximal negative polarity over the suborbital regions. The sources of these peak potentials were localized to the bilateral medial thalamus and cingulate cortical regions. Delta, beta, and gamma oscillations were correlated with the peak amplitude of CPCs during seizures induced during ketamine, whereas delta and gamma oscillations were associated with CPC peaks during etomidate anesthesia (excluding the dose-charge titration).

conclusionsOur findings demonstrate the consistency of CPC presence across participant, stimulus charge, time, and anesthetic agent, with peaks localized to bilateral medial thalamus and cingulate cortical regions and associated with delta, beta, and gamma band oscillations (depending on the anesthetic condition). SIGNIFICANCE: The consistency and reproducibility of CPCs offers ECT as a new avenue for studying the dynamics of generalized seizure activity and thalamocortical networks.

Indexed as

Electroconvulsive TherapyKetamineElectroencephalographyHumansReproducibility of ResultsSeizuresKetamineBrain stimulationElectroconvulsive therapyElectroencephalographyGeneralized seizureMajor depressive disorderThalamocortical network

Identifiers

PMID36549264
PMCPMC10273093
OpenAlexW4312084874

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.