ArticleAsian journal of psychiatry2023
Long term neuropsychiatric consequences in COVID-19 survivors: Cognitive impairment and inflammatory underpinnings fifteen months after discharge.
Article in Asian journal of psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Neurocognitive Impairment in Long COVID: A Systematic Review.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2025Pooled it
- Cognitive function among COVID-19 survivors in the subacute phase during the epidemic of Omicron variant in China.Journal of Zhejiang University. Science. B · 2026Article
- Neurodegenerative and Cognitive Consequences of Long COVID.International journal of molecular sciences · 2026Review
- Sex-Specific Differences in Nutritional Status and Olfaction in Association with Cognitive Impairment Amongst Older Adults with Long COVID Syndrome.Journal of clinical medicine · 2026Article
- Olfactory Dysfunction and Cognitive Decline: Are They Related?Current allergy and asthma reports · 2025Review
- Article
- Exploring the psychological impact of long COVID: symptoms, mechanisms, and treatments.Frontiers in psychiatry · 2025Review
- Infections withFrontiers in aging neuroscience · 2025Review
- Altered functional brain connectivity, efficiency, and information flow associated with brain fog after mild to moderate COVID-19 infection.Scientific reports · 2024Article
- Cognitive performance of post-covid patients in mild, moderate, and severe clinical situations.BMC psychology · 2024Article
- Cognitive decline in post-COVID-19 syndrome does not correspond with persisting neuronal or astrocytic damage.Scientific reports · 2024Article
- Long-Term Risk of Reduced Cognitive Performance and Associated Factors in Discharged Older Adults with COVID-19: A Longitudinal Prospective Study.Annals of geriatric medicine and research · 2024Observational
- Cognition and Memory after Covid-19 in a Large Community Sample.The New England journal of medicine · 2024Article
- Cognitive and mental health trajectories of COVID-19: Role of hospitalisation and long-COVID symptoms.European psychiatry : the journal of the Association of European Psychiatrists · 2024Article
- Psychometric properties of the COVID-19 Yorkshire Rehabilitation Scale: Post-Covid-19 syndrome in Iranian elderly population.BMC infectious diseases · 2024Article
- SARS-CoV-2 Infection Impairs Oculomotor Functions: A Longitudinal Eye-tracking Study.Journal of eye movement research · 2024Article
- Mental health problems raise the odds of cognitive impairment in COVID-19 survivors.Frontiers in psychiatry · 2024Article
- Sex differences in post-acute neurological sequelae of SARS-CoV-2 and symptom resolution in adults after coronavirus disease 2019 hospitalization: an international multi-centre prospective observational study.Brain communications · 2024Article
- Increased Salivary IL-1 Beta Level Is Associated with Poor Sleep Quality in University Students.Diseases (Basel, Switzerland) · 2023Article
- Post-COVID cognitive dysfunction: current status and research recommendations for high risk population.The Lancet regional health. Western Pacific · 2023Review
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEmerging evidence shows that cognitive dysfunction may occur following coronavirus disease 19 (COVID-19) infection which is one of the most common symptoms reported in researches of "Long COVID". Several inflammatory markers are known to be elevated in COVID-19 survivors and the relationship between long-term inflammation changes and cognitive function remains unknown.
methodsWe assessed cognitive function and neuropsychiatric symptoms of 66 COVID-19 survivors and 79 healthy controls (HCs) matched with sex, age, and education level using a digital, gamified cognitive function evaluation tool and questionnaires at 15 months after discharge. Venous blood samples were collected to measure cytokine levels. We performed correlation analyses and multiple linear regression analysis to identify the factors potentially related to cognitive function.
resultsThe COVID-19 survivors performed less well on the Trails (p = 0.047) than the HCs, but most of them did not report subjective neuropsychiatric symptoms. Intensive care unit experience (β = -2.247, p < 0.0001) and self-perceived disease severity (β = -1.522, p = 0.007) were positively correlated, whereas years of education (β = 0.098, p = 0.013) was negatively associated with the performance on the Trails. Moreover, the abnormally elevated TNF-α levels (r = -0.19, p = 0.040) were negatively correlated with performance on the Trails in COVID-19 group.
conclusionOur findings suggest that COVID-19 survivors show long-term cognitive impairment in executive function, even at 15 months after discharge. Serum TNF-α levels may be an underlying mechanism of long-term cognitive impairment in patients recovering from COVID-19.
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