Evidence map›Paper›PMID 36549116›Full record

ArticleEuropean journal of medicinal chemistry2023

Prenylated flavonoids with significant anti-hepatoma activity from Daphne giraldii and effects on Fibroblast Growth Factor Receptor 1 (FGFR1).

Ying Liu, Pinyi Gao, Xiao Liang, Yangyang Zhang, Xiaoqi Yu, Xiaobian Xue, Lara Kockaya, Pankaj Pandey, Robert J Doerksen, Xiaojuan Wang and 6 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of medicinal chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 6 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 2 countries.

Ying LiuSchool of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, PR China.
Pinyi GaoCollege of Pharmaceutical and Biotechnology Engineering, Shenyang University of Chemical Technology, Shenyang, 110142, PR China.
Xiao LiangCollege of Pharmacy, Liaoning University, 66 Chongshan Road, Shenyang, 110036, Liaoning, PR China.
Yangyang ZhangSchool of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, PR China.
Xiaoqi YuSchool of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, PR China.
Xiaobian XueSchool of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, PR China.
Lara KockayaDivision of Medicinal Chemistry, Department of BioMolecular Sciences, University of Mississippi, Mississippi, 38677, USA.
Pankaj PandeyNational Center for Natural Products Research, School of Pharmacy, University of Mississippi, Mississippi, 38677, USA.
Robert J DoerksenDivision of Medicinal Chemistry, Department of BioMolecular Sciences, University of Mississippi, Mississippi, 38677, USA.
Xiaojuan WangSchool of Pharmacy, Lanzhou University, Lanzhou, 730000, Gansu, PR China.
Guodong YaoSchool of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, PR China.
Wanchun ChuSchool of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, PR China.
Xin ChenSchool of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, PR China.
Shaojiang SongSchool of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, PR China.
Mark T HamannCollege of Pharmacy & Medicine, Medical University of South Carolina, Charleston, SC, 29425-5700, USA. Electronic address: hamannm@musc.edu.
Lingzhi LiSchool of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, PR China. Electronic address: lilingzhijessie@163.com.
Shenyang Pharmaceutical University · CNUniversity of Mississippi · USLanzhou University · CNLiaoning University · CNMedical University of South Carolina · USShenyang University of Chemical Technology · CN

Funding

Synthesis and Optimization of the Aleutianamine Class of AlkaloidsR01GM145845 · NIGMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI HAMANN, MARK T, TIUS, MARCUS ANTONIUS · 2022 to 2025
$2.4M
Natural Product HCV Drugs from Rare Plant-Microbe InteractionsR01AT007318 · NCCIH · UNIVERSITY OF MISSISSIPPI · PI HAMANN, MARK T · 2012 to 2016
$1.6M
NCCIH NIH HHS R01 AT007318NIGMS NIH HHS R01 GM145845
6 · The paper itself

Abstract

We report here the orchestration of molecular ion networking (MoIN) and a set of computational and informatics assisted structural elucidation approaches in the discovery of 23 new prenyl-flavonoids and 13 known molecules from Daphne giraldii Nitsche (Thymelaeaceae), some of which possess significant bioactivity against hepatoma carcinoma. Daphnegiratriprenylone A (DPTP-A) represents the class of polyprenyl-flavonoids possessing a triprenyl substitution, and was identified with the guidance of mass spectrometry and nuclear magnetic resonance combined with computational approaches. This approach illustrates a paradigm shift in the application of computational tools for the direct assignment of new natural product structures and it was demonstrated to be reliable compared to conventional 2D-NMR techniques. Seventeen compounds exhibited potent and selective activity against Hep3B cells (IC

Indexed as

Carcinoma, HepatocellularDaphneLiver NeoplasmsFlavonoidsHumansNeopreneReceptor, Fibroblast Growth Factor, Type 1FGFR1 protein, humanFlavonoidsNeopreneprenylReceptor, Fibroblast Growth Factor, Type 1Daphne giraldiiFGFR1 inhibitory activityHep3BMoINPrenyl-flavonoids

Identifiers

PMID36549116
PMCPMC11173874
OpenAlexW4311134861

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.