Evidence map›Paper›PMID 36549112›Full record

ArticleEuropean journal of medicinal chemistry2023

Structure-based lead optimization of peptide-based vinyl methyl ketones as SARS-CoV-2 main protease inhibitors.

Santo Previti, Roberta Ettari, Elsa Calcaterra, Salvatore Di Maro, Stefan J Hammerschmidt, Christin Müller, John Ziebuhr, Tanja Schirmeister, Sandro Cosconati, Maria Zappalà

Abstract read
In one paragraph

Article in European journal of medicinal chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Santo PrevitiDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Stagno d'Alcontres 31, 98166, Messina, Italy. Electronic address: spreviti@unime.it.
Roberta EttariDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Stagno d'Alcontres 31, 98166, Messina, Italy.
Elsa CalcaterraDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Stagno d'Alcontres 31, 98166, Messina, Italy.
Salvatore Di MaroDiSTABiF, University of Campania Luigi Vanvitelli, Via Vivaldi 43, 81100, Caserta, Italy.
Stefan J HammerschmidtInstitute of Pharmaceutical and Biomedical Sciences, University of Mainz, 55128, Mainz, Germany.
Christin MüllerInstitute of Medical Virology Justus Liebig University, Gießen Schubertstr. 81, 35392, Gießen, Germany.
John ZiebuhrInstitute of Medical Virology Justus Liebig University, Gießen Schubertstr. 81, 35392, Gießen, Germany.
Tanja SchirmeisterInstitute of Pharmaceutical and Biomedical Sciences, University of Mainz, 55128, Mainz, Germany.
Sandro CosconatiDiSTABiF, University of Campania Luigi Vanvitelli, Via Vivaldi 43, 81100, Caserta, Italy. Electronic address: sandro.cosconati@unicampania.it.
Maria ZappalàDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Stagno d'Alcontres 31, 98166, Messina, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite several major achievements in the development of vaccines and antivirals, the fight against SARS-CoV-2 and the health problems accompanying COVID-19 are still ongoing. SARS-CoV-2 main protease (M

Indexed as

COVID-19Antiviral AgentsCoronavirus 3C ProteasesHumansKetonesMolecular Docking SimulationPeptidesProtease InhibitorsSARS-CoV-2Viral Nonstructural Proteins3C-like proteinase, SARS-CoV-2Antiviral AgentsCoronavirus 3C ProteasesKetonesPeptidesProtease InhibitorsViral Nonstructural ProteinsAntiviral activityCOVID-19Michael acceptorsPeptide-based inhibitorsSARS-CoV-2 M(pro) inhibition

Identifiers

PMID36549112
PMCPMC9751013

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.