Evidence map›Paper›PMID 36549067›Full record

ArticlePhysica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)2023

Prediction of DNA rejoining kinetics and cell survival after proton irradiation for V79 cells using Geant4-DNA.

Dousatsu Sakata, Ryoichi Hirayama, Wook-Geun Shin, Mauro Belli, Maria A Tabocchini, Robert D Stewart, Oleg Belov, Mario A Bernal, Marie-Claude Bordage, Jeremy M C Brown and 22 more

Erratum issuedAbstract read
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In one paragraph

Article in Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

32 authors.

Dousatsu SakataDepartment of Accelerator and Medical Physics, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology (QST), Chiba 263-8555, Japan; Division of Health Sciences, Osaka University, Osaka 565-0871, Japan. Electronic address: sakata.dousatsu@qst.go.jp.
Ryoichi HirayamaDepartment of Charged Particle Therapy Research, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology (QST), Chiba 263-8555, Japan.
Wook-Geun ShinDepartment of Radiation Oncology, Seoul National University Hospital, Seoul 03080, Republic of Korea.
Mauro BelliIndependent Researcher, Rome, Italy.
Maria A TabocchiniIstituto Nazionale di Fisica Nucleare (INFN)-Roma 1, Rome, Italy.
Robert D StewartDepartment of Radiation Oncology, University of Washington, WA 98195-6043, USA.
Oleg BelovVeksler and Baldin Laboratory of High Energy Physics, Joint Institute for Nuclear Research, 141980 Dubna, Russia; Institute of System Analysis and Management, Dubna State University, 141980 Dubna, Russia.
Mario A BernalInstituto de Fisica Gleb Wataghin, Universidade Estadual de Campinas, Campinas, SP, Brazil.
Marie-Claude BordageINSERM, Université Paul Sabatier, UMR 1037, CRCT, Toulouse, France; Université Toulouse III-Paul Sabatier, UMR 1037, CRCT, Toulouse, France.
Jeremy M C BrownDepartment of Physics and Astronomy, Swinburne University of Technology, Hawthorn, Australia; Centre For Medical Radiation Physics, University of Wollongong, Wollongong, Australia; Department of Radiation Science and Technology, Delft University of Technology, The Netherlands.
Milos DordevicVinca Institute of Nuclear Sciences - National Institute of the Republic of Serbia, University of Belgrade, Belgrade, Serbia.
Dimitris EmfietzoglouMedical Physics Laboratory, Department of Medicine, University of Ioannina, GR 45110, Ioannina, Greece.
Ziad FrancisSaint Joseph University of Beirut, UR Mathématiques et Modélisation, Beirut, Lebanon.
Susanna GuatelliCentre For Medical Radiation Physics, University of Wollongong, Wollongong, Australia.
Taku InaniwaDepartment of Accelerator and Medical Physics, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology (QST), Chiba 263-8555, Japan.
Vladimir IvanchenkoGeant4 Associates International Ltd, Hebden Bridge, UK; Tomsk State University, Tomsk, Russia.
Mathieu KaramitrosIndependent Researcher, Bordeaux, France.
Ioanna KyriakouMedical Physics Laboratory, Department of Medicine, University of Ioannina, GR 45110, Ioannina, Greece.
Nathanael LampeIndependent Researcher, Victoria, Australia.
Zhuxin LiUniv. Bordeaux, CNRS, LP2I Bordeaux, UMR 5797, F-33170 Gradignan, France.
Sylvain MeylanIndependent Researcher, Paris, France.
Claire MicheletUniv. Bordeaux, CNRS, LP2I Bordeaux, UMR 5797, F-33170 Gradignan, France.
Petteri NieminenESA-ESTEC, Noordwijk, The Netherlands.
Yann PerrotIRSN, Institut de Radioprotection et de Surete Nucleaire, 92262 Fontenay-aux-Roses, France.
Ivan PetrovicVinca Institute of Nuclear Sciences - National Institute of the Republic of Serbia, University of Belgrade, Belgrade, Serbia.
Jose Ramos-MendezDepartment of Radiation Oncology, University of California San Francisco, San Francisco 94143, CA, USA.
Aleksandra Ristic-FiraVinca Institute of Nuclear Sciences - National Institute of the Republic of Serbia, University of Belgrade, Belgrade, Serbia.
Giovanni SantinESA-ESTEC, Noordwijk, The Netherlands.
Jan SchuemannPhysics Division, Department of Radiation Oncology, Massachusetts General Hospital & Harvard Medical School, Boston, MA, USA.
Hoang N TranUniv. Bordeaux, CNRS, LP2I Bordeaux, UMR 5797, F-33170 Gradignan, France.
Carmen VillagrasaIRSN, Institut de Radioprotection et de Surete Nucleaire, 92262 Fontenay-aux-Roses, France.
Sebastien IncertiUniv. Bordeaux, CNRS, LP2I Bordeaux, UMR 5797, F-33170 Gradignan, France.

Funding

TOPAS - nBio, a Monte Carlo tool for radiation biology researchR01CA187003 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI SCHUEMANN, JAN PATRICK OSCAR · 2015 to 2024
$4.8M
NCI NIH HHS R01 CA187003
6 · The paper itself

Abstract

purposeTrack structure Monte Carlo (MC) codes have achieved successful outcomes in the quantitative investigation of radiation-induced initial DNA damage. The aim of the present study is to extend a Geant4-DNA radiobiological application by incorporating a feature allowing for the prediction of DNA rejoining kinetics and corresponding cell surviving fraction along time after irradiation, for a Chinese hamster V79 cell line, which is one of the most popular and widely investigated cell lines in radiobiology.

methodsWe implemented the Two-Lesion Kinetics (TLK) model, originally proposed by Stewart, which allows for simulations to calculate residual DNA damage and surviving fraction along time via the number of initial DNA damage and its complexity as inputs.

resultsBy optimizing the model parameters of the TLK model in accordance to the experimental data on V79, we were able to predict both DNA rejoining kinetics at low linear energy transfers (LET) and cell surviving fraction.

conclusionThis is the first study to demonstrate the implementation of both the cell surviving fraction and the DNA rejoining kinetics with the estimated initial DNA damage, in a realistic cell geometrical model simulated by full track structure MC simulations at DNA level and for various LET. These simulation and model make the link between mechanistic physical/chemical damage processes and these two specific biological endpoints.

Indexed as

DNA DamageProtonsAnimalsCell SurvivalCricetinaeDNAKineticsMonte Carlo MethodDNAProtonsCell survivalDNA damageGeant4-DNAMonte Carlo simulation

Identifiers

PMID36549067
PMCPMC11221566

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.