Evidence map›Paper›PMID 36548965›Full record

Observational studyEuropean heart journal. Acute cardiovascular care2023

Association between B-lines on lung ultrasound, invasive haemodynamics, and prognosis in acute heart failure patients.

Junichi Imanishi, Takanori Maeda, Sae Ujiro, Mayuka Masuda, Yuta Kusakabe, Makoto Takemoto, Wataru Fujimoto, Koji Kuroda, Soichiro Yamashita, Masamichi Iwasaki and 2 more

Abstract readObservational Study
In one paragraph

Observational study in European heart journal. Acute cardiovascular care, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Observational
  7. Observational
  8. Article
  9. Imaging of Congestion in Cardio-renal Syndrome.Current heart failure reports · 2025
    Review
  10. Predictors of B-line count in hospitalized patients with COVID-19.Frontiers in cardiovascular medicine · 2025
    Article
  11. Article
  12. Biomarkers of Hemodynamic Congestion in Heart Failure.Current heart failure reports · 2024
    Review
  13. Article
  14. Review
  15. Review
  16. Review
  17. Review
  18. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Junichi ImanishiDepartment of Cardiology, Hyogo Prefectural Awaji Medicine Center, 1-1-137, Shioya, Sumoto-shi, Hyogo 656-0021, Japan.ORCID 0000-0002-1488-1545
Takanori MaedaDepartment of Cardiology, Hyogo Prefectural Awaji Medicine Center, 1-1-137, Shioya, Sumoto-shi, Hyogo 656-0021, Japan.
Sae UjiroDepartment of Cardiology, Hyogo Prefectural Awaji Medicine Center, 1-1-137, Shioya, Sumoto-shi, Hyogo 656-0021, Japan.
Mayuka MasudaDepartment of Cardiology, Hyogo Prefectural Awaji Medicine Center, 1-1-137, Shioya, Sumoto-shi, Hyogo 656-0021, Japan.
Yuta KusakabeDepartment of Cardiology, Hyogo Prefectural Awaji Medicine Center, 1-1-137, Shioya, Sumoto-shi, Hyogo 656-0021, Japan.
Makoto TakemotoDepartment of Cardiology, Hyogo Prefectural Awaji Medicine Center, 1-1-137, Shioya, Sumoto-shi, Hyogo 656-0021, Japan.
Wataru FujimotoDepartment of Cardiology, Hyogo Prefectural Awaji Medicine Center, 1-1-137, Shioya, Sumoto-shi, Hyogo 656-0021, Japan.
Koji KurodaDepartment of Cardiology, Hyogo Prefectural Awaji Medicine Center, 1-1-137, Shioya, Sumoto-shi, Hyogo 656-0021, Japan.
Soichiro YamashitaDepartment of Cardiology, Hyogo Prefectural Awaji Medicine Center, 1-1-137, Shioya, Sumoto-shi, Hyogo 656-0021, Japan.ORCID 0000-0002-8507-6949
Masamichi IwasakiDepartment of Cardiology, Hyogo Prefectural Awaji Medicine Center, 1-1-137, Shioya, Sumoto-shi, Hyogo 656-0021, Japan.
Takahumi TodorokiDepartment of Cardiology, Hyogo Prefectural Awaji Medicine Center, 1-1-137, Shioya, Sumoto-shi, Hyogo 656-0021, Japan.
Masanori OkudaDepartment of Cardiology, Hyogo Prefectural Awaji Medicine Center, 1-1-137, Shioya, Sumoto-shi, Hyogo 656-0021, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsIncreased left atrial pressure leads to pulmonary congestion. Although the B-lines in lung ultrasound (LUS) are useful in detecting pulmonary congestion, data regarding the association between B-lines and invasive haemodynamics are inconsistent. This study aimed to explore the correlation of the B-line count by LUS with pulmonary capillary wedge pressure (PCWP) stratified for preserved and reduced ejection fraction (EF) in acute heart failure patients. METHODS AND

resultsWe performed a prospective observational study on 116 hospitalized patients with acute heart failure (mean age, 75.2 ± 10.3 years), who underwent right heart catheterization before discharge. LUS was performed in eight zones within 4 h of right heart catheterization and compared with PCWP separately in each EF group. Cardiac events were recorded 1 year after discharge. PCWP revealed a clear pivot point at which the B-lines began to increase in the overall cohort and each EF. Specific thresholds of the increase in B-lines were identified at 19 and 25 mmHg for preserved and reduced EF, respectively. Residual congestion at discharge was defined as the presence of ≥6 B-lines. Patients with residual congestion had a higher risk for cardiac events than those without residual congestion (hazard ratio, 12.6; 95% confidence interval, 4.71-33.7; log-rank, P < 0.0001).

conclusionA clear pivot point was associated with increased B-lines count in PCWP at 19 and 25 mmHg for preserved and reduced EF, respectively. Moreover, the increased B-line count above the defined cut-off used to quantify residual congestion was associated with significantly worse outcomes.

Indexed as

Heart FailurePulmonary EdemaAgedAged, 80 and overHemodynamicsHumansLungMiddle AgedPrognosisStroke VolumeUltrasonographyHeart failureInvasive haemodynamicsLung ultrasoundPulmonary congestion

Identifiers

PMID36548965
PMCPMC9910565

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.