ArticleJournal of the American Chemical Society2023
Direct Deaminative Functionalization.
Article in Journal of the American Chemical Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 101 citations in OpenAlex.
- Direct Deaminative Alkynylation of Aliphatic Primary Amines.Angewandte Chemie (International ed. in English) · 2026Article
- Cu-catalyzed deaminative thiocyanation of anilines via nitrate reduction.Molecular diversity · 2026Article
- Beyond traditional defunctionalized cross-coupling reaction: scope, limitations, practicability & future prospects of recent electrochemical methodologies.RSC advances · 2026Review
- Review
- Catalyst-Free Photoinduced Deaminative Functionalization of Amino Acids and Glutarimide Precursors.Journal of the American Chemical Society · 2026Article
- Article
- Anomeric Amides: Valuable Reagents in Synthetic Organic Chemistry.Angewandte Chemie (International ed. in English) · 2026Review
- Larger Substituents Enhance Stereospecificity in 1,1-Diazene Nitrogen Extrusion through Attenuation of Dynamic Mismatching.JACS Au · 2026Article
- Article
- Decoding the Nested, Multicycle Mechanism of Ni-Catalyzed Redox-Neutral Cross-Coupling through Temperature Scanning Reaction Calorimetry.Journal of the American Chemical Society · 2026Article
- Article
- Article
- Deaminative Giese-type reaction.Nature chemistry · 2025Article
- Photocatalyzed C(spOrganic letters · 2025Article
- Accessing sulfonamides via formal SONature chemistry · 2025Article
- Bio-inspired manganese-catalyzed deaminative hydroxylation of benzyl amines to corresponding alcohols.Nature communications · 2025Article
- Catalytic diazene synthesis from sterically hindered amines for deaminative functionalization.Nature communications · 2025Article
- Aliphatic Amines Unlocked for Selective Transformations through Diazotization.Angewandte Chemie (International ed. in English) · 2025Article
- Redox-Tunable Ring Expansion Enabled By A Single-Component Electrophilic Nitrogen Atom Synthon.Angewandte Chemie (International ed. in English) · 2025Article
- Synthesis of Substituted Tetralins via Nitrogen Deletion/Diels-Alder Cascade Reaction.The Journal of organic chemistry · 2024Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
Abstract
Selective functional group interconversions in complex molecular settings underpin many of the challenges facing modern organic synthesis. Currently, a privileged subset of functional groups dominates this landscape, while others, despite their abundance, are sorely underdeveloped. Amines epitomize this dichotomy; they are abundant but otherwise intransigent toward direct interconversion. Here, we report an approach that enables the direct conversion of amines to bromides, chlorides, iodides, phosphates, thioethers, and alcohols, the heart of which is a deaminative carbon-centered radical formation process using an anomeric amide reagent. Experimental and computational mechanistic studies demonstrate that successful deaminative functionalization relies not only on outcompeting the H-atom transfer to the incipient radical but also on the generation of polarity-matched, productive chain-carrying radicals that continue to react efficiently. The overall implications of this technology for interconverting amine libraries were evaluated via high-throughput parallel synthesis and applied in the development of one-pot diversification protocols.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.