Evidence map›Paper›PMID 36548671›Full record

ArticleTropical medicine and infectious disease2022

Evaluation of Chiral Organosulfur Compounds on Their Activity against the Malaria Parasite

Che Julius Ngwa, Rabea Stratmann, Jean Pierre Musabyimana, Kristina Pannen, Jan-Hendrik Schöbel, Marcus Frings, Ingo Schiffers, Calogero Quaranta, Steffen Koschmieder, Nicolas Chatain and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Tropical medicine and infectious disease, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Che Julius NgwaDivision of Cellular and Applied Infection Biology, Institute of Zoology, RWTH Aachen University, 52074 Aachen, Germany.ORCID 0000-0002-1137-1822
Rabea StratmannDivision of Cellular and Applied Infection Biology, Institute of Zoology, RWTH Aachen University, 52074 Aachen, Germany.
Jean Pierre MusabyimanaDivision of Cellular and Applied Infection Biology, Institute of Zoology, RWTH Aachen University, 52074 Aachen, Germany.
Kristina PannenDepartment of Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation, Faculty of Medicine, RWTH Aachen University, 52074 Aachen, Germany.
Jan-Hendrik SchöbelInstitute of Organic Chemistry, RWTH Aachen University, 52074 Aachen, Germany.ORCID 0000-0002-0966-1628
Marcus FringsInstitute of Organic Chemistry, RWTH Aachen University, 52074 Aachen, Germany.
Ingo SchiffersInstitute of Organic Chemistry, RWTH Aachen University, 52074 Aachen, Germany.
Calogero QuarantaInstitute of Organic Chemistry, RWTH Aachen University, 52074 Aachen, Germany.ORCID 0000-0003-1680-1024
Steffen KoschmiederDepartment of Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation, Faculty of Medicine, RWTH Aachen University, 52074 Aachen, Germany.ORCID 0000-0002-1011-8171
Nicolas ChatainDepartment of Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation, Faculty of Medicine, RWTH Aachen University, 52074 Aachen, Germany.ORCID 0000-0003-4485-3120
Gabriele PradelDivision of Cellular and Applied Infection Biology, Institute of Zoology, RWTH Aachen University, 52074 Aachen, Germany.ORCID 0000-0003-2264-5558
Carsten BolmInstitute of Organic Chemistry, RWTH Aachen University, 52074 Aachen, Germany.ORCID 0000-0001-9415-9917
RWTH Aachen University · DE

Funding

the Deutsche Forschungsgemeinschaft NG170/1-1 to C.J.N and PR905/19-1 to G.P
6 · The paper itself

Abstract

Malaria is one of the deadliest tropical diseases, especially causing havoc in children under the age of five in Africa. Although the disease is treatable, the rapid development of drug resistant parasites against frontline drugs requires the search for novel antimalarials. In this study, we tested a series of organosulfur compounds from our internal library for their antiplasmodial effect against

Indexed as

drugsenantiomersmalariaorganosulfur compoundsPlasmodium falciparum

Identifiers

PMID36548671
PMCPMC9785921
OpenAlexW4311529076

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.