Evidence map›Paper›PMID 36548630›Full record

ArticleToxics2022

T Cells Contribute to Pathological Responses in the Non-Targeted Rat Heart following Irradiation of the Kidneys.

Marek Lenarczyk, Ammar J Alsheikh, Eric P Cohen, Dörthe Schaue, Amy Kronenberg, Aron Geurts, Slade Klawikowski, David Mattson, John E Baker

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Emerging evidence for adapting radiotherapy to immunotherapy.Nature reviews. Clinical oncology · 2023
    Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Marek LenarczykRadiation Biosciences, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Ammar J AlsheikhDepartment of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.ORCID 0000-0001-7125-0144
Eric P CohenDepartment of Medicine, Division of Nephrology, New York University, New York, NY 10016, USA.
Dörthe SchaueDepartment of Radiation Oncology, University of California at Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0002-5674-678X
Amy KronenbergBiological Systems and Engineering, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
Aron GeurtsDepartment of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Slade KlawikowskiDepartment of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
David MattsonDepartment of Physiology, Medical College of Georgia, Augusta, GA 30912, USA.
John E BakerRadiation Biosciences, Medical College of Wisconsin, Milwaukee, WI 53226, USA.ORCID 0000-0001-7899-3266
Medical College of Wisconsin · USAugusta University · USLawrence Berkeley National Laboratory · USNew York University · USUniversity of California, Los Angeles · US

Funding

Foundation for Heart Science Unrestricted grantNASA NNX15AD69G, 80NSSC19K0498
6 · The paper itself

Abstract

Heart disease is a significant adverse event caused by radiotherapy for some cancers. Identifying the origins of radiogenic heart disease will allow therapies to be developed. Previous studies showed non-targeted effects manifest as fibrosis in the non-irradiated heart after 120 days following targeted X-irradiation of the kidneys with 10 Gy in WAG/RijCmcr rats. To demonstrate the involvement of T cells in driving pathophysiological responses in the out-of-field heart, and to characterize the timing of immune cell engagement, we created and validated a T cell knock downrat on the WAG genetic backgrou nd. Irradiation of the kidneys with 10 Gy of X-rays in wild-type rats resulted in infiltration of T cells, natural killer cells, and macrophages after 120 days, and none of these after 40 days, suggesting immune cell engagement is a late response. The radiation nephropathy and cardiac fibrosis that resulted in these animals after 120 days was significantly decreased in irradiated T cell depleted rats. We conclude that T cells function as an effector cell in communicating signals from the irradiated kidneys which cause pathologic remodeling of non-targeted heart.

Indexed as

cardiac fibrosisheartimmune systemkeyword radiationkidneynephropathyratT cell knock down

Identifiers

PMID36548630
PMCPMC9783591
OpenAlexW4312196567

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.