Evidence map›Paper›PMID 36548589›Full record

ArticleToxics2022

Copper and Zinc Treatments Alter the Thyroid Endocrine System in Zebrafish Embryos/Larvae.

Liqiao Zhong, He Zhang, Luyin Wu, Huijun Ru, Nian Wei, Fan Yao, Zhaohui Ni, Xinbin Duan, Yunfeng Li

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Mediation effects of thyroid hormones in the associations between essential metal elements and anxiety or depression symptoms in the elderly.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026
    Article
  3. Copper-Induced Thyroid Disruption and Oxidative Stress inAntioxidants (Basel, Switzerland) · 2026
    Article
  4. Article
  5. Blood Biochemical Biomarkers in Fish Toxicology-A Review.Animals : an open access journal from MDPI · 2025
    Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Liqiao ZhongFishery Resources and Environmental Science Experimental Station of the Upper-Middle Reaches of Yangtze River (Ministry of Agriculture and Rural Affairs), Yangtze River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Wuhan 430223, China.ORCID 0000-0001-5524-449X
He ZhangZhejiang Provincial Key Lab for Subtropical Water Environment and Marine Biological Resources Protection, College of Life and Environmental Science, Wenzhou University, Wenzhou 325035, China.ORCID 0000-0001-9979-4688
Luyin WuFishery Resources and Environmental Science Experimental Station of the Upper-Middle Reaches of Yangtze River (Ministry of Agriculture and Rural Affairs), Yangtze River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Wuhan 430223, China.
Huijun RuFishery Resources and Environmental Science Experimental Station of the Upper-Middle Reaches of Yangtze River (Ministry of Agriculture and Rural Affairs), Yangtze River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Wuhan 430223, China.
Nian WeiFishery Resources and Environmental Science Experimental Station of the Upper-Middle Reaches of Yangtze River (Ministry of Agriculture and Rural Affairs), Yangtze River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Wuhan 430223, China.
Fan YaoFishery Resources and Environmental Science Experimental Station of the Upper-Middle Reaches of Yangtze River (Ministry of Agriculture and Rural Affairs), Yangtze River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Wuhan 430223, China.
Zhaohui NiFishery Resources and Environmental Science Experimental Station of the Upper-Middle Reaches of Yangtze River (Ministry of Agriculture and Rural Affairs), Yangtze River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Wuhan 430223, China.
Xinbin DuanFishery Resources and Environmental Science Experimental Station of the Upper-Middle Reaches of Yangtze River (Ministry of Agriculture and Rural Affairs), Yangtze River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Wuhan 430223, China.
Yunfeng LiFishery Resources and Environmental Science Experimental Station of the Upper-Middle Reaches of Yangtze River (Ministry of Agriculture and Rural Affairs), Yangtze River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Wuhan 430223, China.
Ministry of Agriculture and Rural Affairs · CNWenzhou University · CN

Funding

the Central Public-interest Scientific Institution Basal Research Fund, the Chinese Academy of Fishery Sciences 2020TD09, 2022JC01the China Three Gorges Project Corporation 0799555The National Key Research and Development Program of China 2018YFD0900903the Open Research Fund Program of State Key Laboratory of Biocatalysis and Enzyme Engineering, Hubei University SKLBEE2021006
6 · The paper itself

Abstract

Copper (Cu

Indexed as

copper and zinchypothalamus-pituitary-thyroid axisthyroid disruptionzebrafish

Identifiers

PMID36548589
PMCPMC9788113
OpenAlexW4311627269

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.