Evidence map›Paper›PMID 36548427›Full record

ArticleScience (New York, N.Y.)2022

Glassfrogs conceal blood in their liver to maintain transparency.

Carlos Taboada, Jesse Delia, Maomao Chen, Chenshuo Ma, Xiaorui Peng, Xiaoyi Zhu, Laiming Jiang, Tri Vu, Qifa Zhou, Junjie Yao and 2 more

Open access · greenAbstract read
In one paragraph

Article in Science (New York, N.Y.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 44 citations in OpenAlex.

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  14. Label-Free 3D Photoacoustic Imaging of Tumor Organoids for Volumetric Drug Screening.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Carlos Taboada *Biology Department, Duke University, Durham, NC, USA.ORCID 0000-0002-7074-1897
Jesse Delia *Department of Biomedical Engineering, Duke University, Durham, NC, USA.ORCID 0000-0001-9845-8690
Maomao Chen *Department of Biomedical Engineering, Duke University, Durham, NC, USA.ORCID 0000-0003-3692-1138
Chenshuo MaDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.ORCID 0000-0001-9701-2566
Xiaorui PengDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.ORCID 0000-0001-5756-7591
Xiaoyi ZhuDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.
Laiming JiangDepartment of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USA.ORCID 0000-0002-8658-3168
Tri VuDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.
Qifa ZhouDepartment of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USA.
Junjie YaoDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.ORCID 0000-0002-2381-706X
Lauren O'ConnellDepartment of Biology, Stanford University, Stanford, CA, USA.ORCID 0000-0002-2706-4077
Sönke JohnsenBiology Department, Duke University, Durham, NC, USA.ORCID 0000-0002-3943-8320
Duke University · USUniversity of Southern California · USAmerican Museum of Natural History · USStanford University · US

Funding

High-resolution High-speed Photoacoustic and Ultrasound Imaging of SmallVessel Functions in Ischemic StrokeR01NS111039 · NINDS · DUKE UNIVERSITY · PI YAO, JUNJIE · 2019 to 2023
$2.7M
Head-mounted Photoacoustic Imaging of Deep-brain Neural Activities in Freely Behaving AnimalsRF1NS115581 · NINDS · DUKE UNIVERSITY · PI VERKHUSHA, VLADISLAV, YAO, JUNJIE · 2020 to 2020
$2.0M
High-Throughput Volumetric Photoacoustic Imaging of Living Vascularized OrganoidsR01EB028143 · NIBIB · DUKE UNIVERSITY · PI YAO, JUNJIE · 2019 to 2022
$2.0M
NIBIB NIH HHS R01 EB028143NINDS NIH HHS R01 NS111039NINDS NIH HHS RF1 NS115581
6 · The paper itself

Abstract

Transparency in animals is a complex form of camouflage involving mechanisms that reduce light scattering and absorption throughout the organism. In vertebrates, attaining transparency is difficult because their circulatory system is full of red blood cells (RBCs) that strongly attenuate light. Here, we document how glassfrogs overcome this challenge by concealing these cells from view. Using photoacoustic imaging to track RBCs in vivo, we show that resting glassfrogs increase transparency two- to threefold by removing ~89% of their RBCs from circulation and packing them within their liver. Vertebrate transparency thus requires both see-through tissues and active mechanisms that "clear" respiratory pigments from these tissues. Furthermore, glassfrogs' ability to regulate the location, density, and packing of RBCs without clotting offers insight in metabolic, hemodynamic, and blood-clot research.

Indexed as

AnuraBiological MimicryBlood CoagulationErythrocytesLiverAnimalsErythrocyte CountHemodynamicsOptical Phenomena

Identifiers

PMID36548427
PMCPMC9984244
OpenAlexW4312190854

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.