ArticlePLoS computational biology2022
Mechanistic model for human brain metabolism and its connection to the neurovascular coupling.
Article in PLoS computational biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed.
- High-temporal resolution metabolic connectivity resolved by component-based noise correction.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026Article
- Complementarity of BOLD and ADC-fMRI in Mapping Brain Visual Processing in the Rat.NMR in biomedicine · 2026Article
- Distinct neurologic state in patients with traumatic brain injury and hemorrhagic stroke during the stage of acute disorders of consciousness and the correlation with the neurological prognosis: A multi-modal PET/rs-fMRI study.NeuroImage. Clinical · 2026Article
- Modelling brain metabolism with interacting nonautonomous phase oscillators.Frontiers in network physiology · 2026Article
- Associations between incremental exercise capacity and multimodal brain characteristics across training levels.Frontiers in human neuroscience · 2026Article
- Brain metabolic-functional (de)coupling from health to glioma dysfunction.Communications biology · 2025Article
- Somatosensory-evoked response induces extensive diffusivity and kurtosis changes associated with neural activity in rodents.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Association of Blood Metabolomics Biomarkers with Brain Metabolites and Patient-Reported Outcomes as a New Approach in Individualized Diagnosis of Schizophrenia.International journal of molecular sciences · 2024Article
- The causal relationship between human brain morphometry and knee osteoarthritis: a two-sample Mendelian randomization study.Frontiers in genetics · 2024Article
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6 authors.
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Abstract
The neurovascular and neurometabolic couplings (NVC and NMC) connect cerebral activity, blood flow, and metabolism. This interconnection is used in for instance functional imaging, which analyses the blood-oxygen-dependent (BOLD) signal. The mechanisms underlying the NVC are complex, which warrants a model-based analysis of data. We have previously developed a mechanistically detailed model for the NVC, and others have proposed detailed models for cerebral metabolism. However, existing metabolic models are still not fully utilizing available magnetic resonance spectroscopy (MRS) data and are not connected to detailed models for NVC. Therefore, we herein present a new model that integrates mechanistic modelling of both MRS and BOLD data. The metabolic model covers central metabolism, using a minimal set of interactions, and can describe time-series data for glucose, lactate, aspartate, and glutamate, measured after visual stimuli. Statistical tests confirm that the model can describe both estimation data and predict independent validation data, not used for model training. The interconnected NVC model can simultaneously describe BOLD data and can be used to predict expected metabolic responses in experiments where metabolism has not been measured. This model is a step towards a useful and mechanistically detailed model for cerebral blood flow and metabolism, with potential applications in both basic research and clinical applications.
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