Evidence map›Paper›PMID 36548377›Full record

ArticleAmerican journal on intellectual and developmental disabilities2023

FMR1 CGG Repeats and Stress Influence Self-Reported Cognitive Functioning in Mothers.

Nell Maltman, Leann Smith DaWalt, Jinkuk Hong, Mei Wang Baker, Elizabeth M Berry-Kravis, Murray H Brilliant, Marsha Mailick

Open access · greenAbstract read
In one paragraph

Article in American journal on intellectual and developmental disabilities, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Cognitive-behavioral phenotypes inFrontiers in molecular neuroscience · 2026
    Article
  3. Article
  4. Reduced Respiratory Sinus Arrhythmia in Infants with theInternational journal of molecular sciences · 2025
    Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Evidence for Three Subgroups of FemaleFrontiers in integrative neuroscience · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Nell MaltmanNell Maltman, Leann Smith DaWalt, and Jinkuk Hong, University of Wisconsin-Madison.
Leann Smith DaWaltNell Maltman, Leann Smith DaWalt, and Jinkuk Hong, University of Wisconsin-Madison.
Jinkuk HongNell Maltman, Leann Smith DaWalt, and Jinkuk Hong, University of Wisconsin-Madison.
Mei Wang BakerMei Wang Baker, Wisconsin State Laboratory of Hygiene.
Elizabeth M Berry-KravisElizabeth M. Berry-Kravis, Rush University Medical Center.
Murray H BrilliantMurray H. Brilliant and Marsha Mailick, University of Wisconsin-Madison.
Marsha MailickMurray H. Brilliant and Marsha Mailick, University of Wisconsin-Madison.
University of Wisconsin–Madison · USBerry (United States) · US

Funding

POSTDOCTORAL TRAINING IN MENTAL RETARDATION RESEARCHT32HD007489 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI Sigan L Hartley · 1995 to 2026
$6.0M
Waisman Intellectual and Developmental Disabilities Research Center Down Syndrome RegistryU54HD090256 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI CHANG, QIANG · 2016 to 2020
$6.0M
FMR1 Premutation Phenotypes in Population-Based & Clinically-Ascertained SamplesR01HD082110 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI Leann Smith DaWalt, MARSHA RUTH MAILICK · 2015 to 2026
$5.1M
NICHD NIH HHS R01 HD082110NICHD NIH HHS T32 HD007489NICHD NIH HHS U54 HD090256
6 · The paper itself

Abstract

Variation in the FMR1 gene may affect aspects of cognition, such as executive function and memory. Environmental factors, such as stress, may also negatively impact cognitive functioning. Participants included 1,053 mothers of children with and without developmental disabilities. Participants completed self-report measures of executive function, memory, and stress (i.e., life events, parenting status), and provided DNA to determine CGG repeat length (ranging from 7 to 192 CGGs). Stress exposure significantly predicted greater self-reported difficulties in executive function and the likelihood of memory problems. Cubic CGG effects independently predicted executive function and memory difficulties, suggesting effects of both genetic variation and environmental stress exposure on cognitive functioning.

Indexed as

CognitionFragile X Messenger Ribonucleoprotein 1MothersStress, PsychologicalTrinucleotide Repeat ExpansionChildExecutive FunctionFemaleHumansSelf ReportFMR1 protein, humanFragile X Messenger Ribonucleoprotein 1CGG repeatscognitive functioningexecutive functionFMR1memorystress

Identifiers

PMID36548377
PMCPMC10445796
OpenAlexW4312190563

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.