Evidence map›Paper›PMID 36548338›Full record

Trial reportPloS one2022

Randomized controlled trial of early aerobic exercise following sport-related concussion: Progressive percentage of age-predicted maximal heart rate versus usual care.

Michael G Hutchison, Alex P Di Battista, David W Lawrence, Kyla Pyndiura, Danielle Corallo, Doug Richards

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02969824 (Post-acute Structured Exercise Following Sport Concussion), which is not on this map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02969824 naterminatednot on this map

Post-acute Structured Exercise Following Sport Concussion: a Randomized Controlled Study

TypeinterventionalSponsorUniversity of TorontoRan2017 to 2020Enrolled50ConditionsConcussion, BrainArmsSupervised Aerobic Exercise
3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Michael G HutchisonFaculty of Kinesiology and Physical Education, University of Toronto, Toronto, Ontario, Canada.
Alex P Di BattistaFaculty of Kinesiology and Physical Education, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0002-3325-6833
David W LawrenceFaculty of Kinesiology and Physical Education, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0002-1386-7127
Kyla PyndiuraFaculty of Kinesiology and Physical Education, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0002-3608-4109
Danielle CoralloFaculty of Kinesiology and Physical Education, University of Toronto, Toronto, Ontario, Canada.
Doug RichardsFaculty of Kinesiology and Physical Education, University of Toronto, Toronto, Ontario, Canada.
University of Toronto · CADefence Research and Development Canada · CASt. Michael's Hospital · CA

Funding

CIHR 155945
6 · The paper itself

Abstract

objectiveTo examine the effect of a readily accessible, structured aerobic exercise intervention on days to asymptomatic status and days to medical clearance compared to usual care exercise prescription in a cohort of adolescents and young adults following sport-related concussion (SRC).

methodsA longitudinal, randomized, non-blinded clinical trial consisting of a structured aerobic exercise protocol (SAEP) group and a usual care exercise prescription (UCEP) group. Participants in the SAEP group underwent an exercise protocol including 8 sessions over 11 days progressing in duration and intensity stepwise based on participants' age-predicted maximal heart rate. Symptom follow-ups were on days 7, 14, 21, and 28. The primary outcome measures of the study were days to asymptomatic status and days to medical clearance, while the secondary outcome measure was symptom severity on days 7, 14, 21, and 28.

results38 participants (SAEP, n = 20; UCEP, n = 19) were recruited and completed all follow-up appointments. Compared to the UCEP group, the SAEP had a faster time to asymptomatic status with 96% posterior probability. In addition, the SAEP group displayed an earlier time to medical clearance with 93% posterior probability. While symptom severity scores did not differ between groups at enrolment (SAEP symptom severity, 30; UCEP, 29), they were subsequently lower in the SAEP group at all assessments throughout the trial with 100% posterior probability.

conclusionsAn aerobic exercise protocol based on percentages of age-predicted maximum heart rate is a safe and effective treatment for reducing symptoms and can be initiated during the first week following SRC.

trial registrationClinicalTrials.gov, no. NCT02969824.

Indexed as

Brain ConcussionSportsAdolescentExerciseExercise TherapyHeart RateHumansYoung Adult

Identifiers

PMID36548338
PMCPMC9778585
OpenAlexW4312090041

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.