Evidence map›Paper›PMID 36548281›Full record

ArticlePloS one2022

Protocol for a randomized study assessing the feasibility of home-based albuminuria screening among the general population: The THOMAS study.

Dominique van Mil, Lyanne M Kieneker, Birgitte Evers-Roeten, Marc H M Thelen, Hanne de Vries, Marc H Hemmelder, Annemiek Dorgelo, Ronald W van Etten, Hiddo J L Heerspink, Ron T Gansevoort

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04295889 (Towards HOMe-based Albuminuria Screening), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04295889 naunknown statusnot on this map

Towards HOMe-based Albuminuria Screening: an Implementation Study Testing Two Approaches

TypeinterventionalSponsorUniversity Medical Center GroningenRan2019 to 2022Enrolled15,032ConditionsAlbuminuriaArmsApproach A (PeeSpot urine collection device)., Approach B (ACR, EU Test kit).
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Dominique van MilDivision of Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.ORCID 0000-0002-3477-9310
Lyanne M KienekerDivision of Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Birgitte Evers-RoetenGeneral Practice Tholos, Zevenbergen, The Netherlands.
Marc H M ThelenResult Laboratory and Clinical Chemistry, Amphia Hospital, Breda, The Netherlands.
Hanne de VriesDepartment of Internal Medicine, Jeroen Bosch Hospital, 's-Hertogenbosch, The Netherlands.
Marc H HemmelderDepartment of Internal Medicine, CARIM Cardiovascular Research Institute, Maastricht University Medical Center, University Maastricht, Maastricht, The Netherlands.
Annemiek DorgeloDutch Kidney Foundation, Bussum, The Netherlands.
Ronald W van EttenDepartment of Internal Medicine, Amphia Hospital, Breda, The Netherlands.
Hiddo J L HeerspinkDepartment of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Ron T GansevoortDivision of Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
University Medical Center Groningen · NLAmphia Ziekenhuis · NLJeroen Bosch Ziekenhuis · NLMaastricht University · NLNierstichting · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChronic kidney disease (CKD) is a rising public health problem that may progress to kidney failure, requiring kidney replacement therapy. It is also associated with an increased incidence of cardiovascular disease (CVD). Because of its asymptomatic nature, CKD is often detected in a late stage. Population screening for albuminuria could allow early detection of people with CKD who may benefit from preventive treatment. In case such screening is performed in a general practitioner (GP) setting, this will result in relatively high costs. Home-based screening might be an effective and cost-effective alternative.

aimThe THOMAS study (Towards HOMe-based Albuminuria Screening) is designed to prospectively investigate two methods for home-based population screening for increased albuminuria to detect yet undiagnosed CKD and risk factors for progression and CVD.

methodsThis investigator initiated, randomized population-based study will include 15.000 individuals aged 45-80 years, who will be randomly assigned to be invited for a home-based screening test for albuminuria with a more conventional urine collection device or an innovative smartphone application. If the test result is positive upon confirmation (i.e., elevated albuminuria), participants are invited to a central screening facility for an elaborate screening for CKD and CVD risk factors. Participants are referred to their GP for appropriate treatment, if abnormalities are found. Primary endpoints are the participation rate, yield, and cost-effectiveness of the home-based screening and elaborate screening.

conclusionsThe THOMAS study will evaluate the effectiveness and cost-effectiveness of home-based albuminuria screening in the general population for the early detection of CKD and CVD risk factors. It will provide insight into the willingness to participate in population screening for CKD and into the compliance of the general population to a corresponding screening protocol and compliance to participate. Thus, it may help to develop an attractive novel screening strategy for the early detection of CKD.

trial registrationClinicalTrials.gov, registration number NCT04295889, registered 05 March 2020. https://www.google.com/search?client=firefox-b-d&q=NCT04295889.

Indexed as

Cardiovascular DiseasesRenal Insufficiency, ChronicAlbuminuriaFeasibility StudiesHumansMass ScreeningRandomized Controlled Trials as Topic

Identifiers

PMID36548281
PMCPMC9778938
OpenAlexW4312091471

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.