ArticlePLoS genetics2022
Mating disrupts morning anticipation in Drosophila melanogaster females.
Article in PLoS genetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 17 citations in OpenAlex.
- Circadian control of a sex-specific behavior ineLife · 2026Article
- Characterization of the post-mating responses of Drosophila hydei, a species that lacks Sex-Peptide.Communications biology · 2026Article
- Article
- A millisecond parameter space for phase-shifting the circadian pacemaker with near-ultraviolet light.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2025Article
- Article
- FlyVISTA, an integrated machine learning platform for deep phenotyping of sleep inScience advances · 2025Article
- Effects of sex, mating status, and genetic background on circadian behavior inbioRxiv : the preprint server for biology · 2024Article
- FlyVISTA, an Integrated Machine Learning Platform for Deep Phenotyping of Sleep inbioRxiv : the preprint server for biology · 2024Article
- Effects of sex, mating status, and genetic background on circadian behavior inFrontiers in neuroscience · 2024Article
- Genetic atlas of hygro-and thermosensory cells in the vinegar fly Drosophila melanogaster.Scientific reports · 2023Article
- Time series transcriptome analysis implicates the circadian clock in theProceedings of the National Academy of Sciences of the United States of America · 2023Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
After mating, the physiology of Drosophila females undergo several important changes, some of which are reflected in their rest-activity cycles. To explore the hypothesis that mating modifies the temporal organization of locomotor activity patterns, we recorded fly activity by a video tracking method. Monitoring rest-activity patterns under light/dark (LD) cycles indicated that mated females lose their ability to anticipate the night-day transition, in stark contrast to males and virgins. This postmating response is mediated by the activation of the sex peptide receptor (SPR) mainly on pickpocket (ppk) expressing neurons, since reducing expression of this receptor in these neurons restores the ability to anticipate the LD transition in mated females. Furthermore, we provide evidence of connectivity between ppk+ neurons and the pigment-dispersing factor (PDF)-positive ventral lateral neurons (sLNv), which play a central role in the temporal organization of daily activity. Since PDF has been associated to the generation of the morning activity peak, we hypothesized that the mating signal could modulate PDF levels. Indeed, we confirm that mated females have reduced PDF levels at the dorsal protocerebrum; moreover, SPR downregulation in ppk+ neurons mimics PDF levels observed in males. In sum, our results are consistent with a model whereby mating-triggered signals reach clock neurons in the fly central nervous system to modulate the temporal organization of circadian behavior according to the needs of the new status.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.