Evidence map›Paper›PMID 36548181›Full record

ArticleNon-coding RNA2022

Is Evolutionary Conservation a Useful Predictor for Cancer Long Noncoding RNAs? Insights from the Cancer LncRNA Census 3.

Adrienne Vancura, Alejandro H Gutierrez, Thorben Hennig, Carlos Pulido-Quetglas, Frank J Slack, Rory Johnson, Simon Haefliger

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Non-coding RNA, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Adrienne VancuraDepartment of Medical Oncology, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland.ORCID 0000-0002-7990-0559
Alejandro H GutierrezDepartment of Medical Oncology, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland.ORCID 0000-0003-3086-1971
Thorben HennigHMS Initiative for RNA Medicine, Department of Pathology, Beth Israel Deaconess Medical Center Cancer Center, Harvard Medical School, Boston, MA 02215, USA.ORCID 0000-0001-6683-8269
Carlos Pulido-QuetglasDepartment of Medical Oncology, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland.ORCID 0000-0001-6164-3614
Frank J SlackHMS Initiative for RNA Medicine, Department of Pathology, Beth Israel Deaconess Medical Center Cancer Center, Harvard Medical School, Boston, MA 02215, USA.ORCID 0000-0001-8263-0409
Rory JohnsonDepartment of Medical Oncology, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland.
Simon HaefligerDepartment of Medical Oncology, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland.ORCID 0000-0002-9721-3314

Funding

Precision microRNA medicine in cancerR35CA232105 · NCI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI SLACK, FRANK J. · 2019 to 2025
$7.2M
NCI NIH HHS R35 CA232105Regenerative strategies for heart disease via targeting the long noncoding transcriptome 173738Science Foundation Ireland through Future Research Leaders award 18/FRL/6194SNF Doc.mobility project P1BEP3_199932The elements of long noncoding RNA function 31003A_182337the Helmut Horten Stiftung, Swiss Cancer Research Foundation 4534-08-2018the Swiss National Science Foundation through the National Centre of Competence in Research (NCCR) "RNA & Disease" 51NF40-182880
6 · The paper itself

Abstract

Evolutionary conservation is a measure of gene functionality that is widely used to prioritise long noncoding RNAs (lncRNA) in cancer research. Intriguingly, while updating our Cancer LncRNA Census (CLC), we observed an inverse relationship between year of discovery and evolutionary conservation. This observation is specific to cancer over other diseases, implying a sampling bias in the selection of lncRNA candidates and casting doubt on the value of evolutionary metrics for the prioritisation of cancer-related lncRNAs.

Indexed as

cancerconservationlong noncoding RNA

Identifiers

PMID36548181
PMCPMC9785742

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.