Evidence map›Paper›PMID 36548126›Full record

ArticleACS nano2023

Wireless, Battery-Free Implants for Electrochemical Catecholamine Sensing and Optogenetic Stimulation.

Tucker Stuart, William J Jeang, Richard A Slivicki, Bobbie J Brown, Alex Burton, Victoria E Brings, Lilian C Alarcón-Segovia, Prophecy Agyare, Savanna Ruiz, Amanda Tyree and 11 more

Open access · greenAbstract read
In one paragraph

Article in ACS nano, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
4.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 51 citations in OpenAlex.

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  15. Living-Neuron-Based Autogenerator.Sensors (Basel, Switzerland) · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 4 institutions in 1 country.

Tucker StuartDepartment of Biomedical Engineering, University of Arizona, Tucson, Arizona 85721, United States.ORCID 0000-0002-4643-6868
William J JeangDepartment of Materials Science and Engineering, Northwestern University, Evanston, Illinois 60201, United States.ORCID 0000-0002-5401-8535
Richard A SlivickiDepartment of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri 63110, United States.
Bobbie J BrownDepartment of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri 63110, United States.
Alex BurtonDepartment of Biomedical Engineering, University of Arizona, Tucson, Arizona 85721, United States.ORCID 0000-0001-7182-0696
Victoria E BringsDepartment of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri 63110, United States.
Lilian C Alarcón-SegoviaQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, Illinois 60201, United States.
Prophecy AgyareDepartment of Neuroscience, Northwestern University, Evanston, Illinois 60201, United States.
Savanna RuizDepartment of Materials Science and Engineering, Northwestern University, Evanston, Illinois 60201, United States.
Amanda TyreeDepartment of Biomedical Engineering, University of Arizona, Tucson, Arizona 85721, United States.
Lindsay PruittDepartment of Biomedical Engineering, University of Arizona, Tucson, Arizona 85721, United States.
Surabhi MadhvapathyDepartment of Materials Science and Engineering, Northwestern University, Evanston, Illinois 60201, United States.
Martin NiemiecDepartment of Biomedical Engineering, University of Arizona, Tucson, Arizona 85721, United States.
James ZhuangDepartment of Biomedical Engineering, University of Arizona, Tucson, Arizona 85721, United States.
Siddharth KrishnanQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, Illinois 60201, United States.
Bryan A CopitsDepartment of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri 63110, United States.
John A RogersDepartment of Materials Science and Engineering, Northwestern University, Evanston, Illinois 60201, United States.ORCID 0000-0002-2980-3961
Robert W GereauDepartment of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri 63110, United States.
Vijay K SamineniDepartment of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri 63110, United States.
Amay J BandodkarDepartment of Electrical and Computer Engineering, North Carolina State University, Raleigh, North Carolina 27606, United States.ORCID 0000-0002-1792-1506
Philipp GutrufDepartment of Biomedical Engineering, University of Arizona, Tucson, Arizona 85721, United States.
Northwestern University · USUniversity of Arizona · USWashington University in St. Louis · USNorth Carolina State University · US

Funding

CNS Mechanisms of IC/BPSR01DK116178 · NIDDK · WASHINGTON UNIVERSITY · PI Robert W Gereau · 2018 to 2026
$5.6M
MECHANISMS OF CENTRAL SENSITIZATIONR01NS048602 · NINDS · WASHINGTON UNIVERSITY · PI GEREAU, ROBERT W · 2004 to 2014
$4.2M
Mechanisms of Central SensitizationR01NS106953 · NINDS · WASHINGTON UNIVERSITY · PI GEREAU, ROBERT W · 2018 to 2022
$2.7M
Neural Mechanisms Underlying IC/BPSR01DK128475 · NIDDK · WASHINGTON UNIVERSITY · PI SAMINENI, VIJAY K · 2021 to 2025
$2.3M
Training in Computational Neural EngineeringT32EB025816 · NIBIB · GEORGIA INSTITUTE OF TECHNOLOGY · PI Michael Robert Borich, Christopher John Rozell · 2019 to 2026
$1.9M
DEFINING THE NEURAL BASIS FOR CHRONIC BLADDER PAIN AND ITS ASSOCIATED COMORBID DISORDERSK01DK115634 · NIDDK · WASHINGTON UNIVERSITY · PI SAMINENI, VIJAY K · 2018 to 2022
$582k
Evaluation of peripheral cannabinoid receptors as a target for pain managementF32DA051160 · NIDA · WASHINGTON UNIVERSITY · PI SLIVICKI, RICHARD · 2020 to 2022
$187k
Howard Hughes Medical InstituteNIBIB NIH HHS T32 EB025816NIDA NIH HHS F32 DA051160NIDDK NIH HHS K01 DK115634NIDDK NIH HHS R01 DK116178NIDDK NIH HHS R01 DK128475NINDS NIH HHS R01 NS048602NINDS NIH HHS R01 NS106953
6 · The paper itself

Abstract

Neurotransmitters and neuromodulators mediate communication between neurons and other cell types; knowledge of release dynamics is critical to understanding their physiological role in normal and pathological brain function. Investigation into transient neurotransmitter dynamics has largely been hindered due to electrical and material requirements for electrochemical stimulation and recording. Current systems require complex electronics for biasing and amplification and rely on materials that offer limited sensor selectivity and sensitivity. These restrictions result in bulky, tethered, or battery-powered systems impacting behavior and that require constant care of subjects. To overcome these challenges, we demonstrate a fully implantable, wireless, and battery-free platform that enables optogenetic stimulation and electrochemical recording of catecholamine dynamics in real time. The device is nearly 1/10th the size of previously reported examples and includes a probe that relies on a multilayer electrode architecture featuring a microscale light emitting diode (μ-LED) and a carbon nanotube (CNT)-based sensor with sensitivities among the highest recorded in the literature (1264.1 nA μM

Indexed as

CatecholaminesOptogeneticsAnimalsDopamineMiceProstheses and ImplantsWireless TechnologyCatecholaminesDopaminebattery-freecarbon nanotubescatecholaminedopamineoptogeneticswireless

Identifiers

PMID36548126
PMCPMC11801802
OpenAlexW4312193168

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.