Evidence map›Paper›PMID 36548124›Full record

ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2023

Appendicular Lean Mass, Grip Strength, and the Incidence of Dementia Among Older Adults in the Health ABC Study.

James S Andrews, Laura S Gold, May J Reed, Catherine L Hough, Jose M Garcia, Robyn L McClelland, Annette L Fitzpatrick, Ken E Covinsky, Paul K Crane, Kristine Yaffe and 1 more

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In one paragraph

Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

James S AndrewsDepartment of Medicine, University of Washington, Seattle, Washington, USA.ORCID 0000-0003-2302-4358
Laura S GoldDepartment of Radiology, University of Washington, Seattle, Washington, USA.
May J ReedDepartment of Medicine, University of Washington, Seattle, Washington, USA.
Catherine L HoughDepartment of Medicine, Oregon Health & Science University, Portland, Oregon, USA.
Jose M GarciaDepartment of Medicine, University of Washington, Seattle, Washington, USA.
Robyn L McClellandDepartment of Biostatistics, University of Washington, Seattle, Washington, USA.
Annette L FitzpatrickDepartments of Family Medicine, Epidemiology, and Global Health, University of Washington, Seattle, Washington, USA.
Ken E CovinskyDepartment of Medicine, University of California San Francisco, San Francisco, California, USA.
Paul K CraneDepartment of Medicine, University of Washington, Seattle, Washington, USA.
Kristine YaffeDepartments of Psychiatry, Neurology, and Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, USA.
Peggy M CawthonCalifornia Pacific Medical Center Research Institute, and University of California San Francisco, San Francisco, California, USA.ORCID 0000-0003-4938-9478

Funding

VARC CoreP30AG044281 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Louise C. Walter · 2013 to 2026
$19.9M
Peripheral Nerve Function Decline in an Aged CohortR01AG028050 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI STROTMEYER, ELSA S. · 2007 to 2015
$3.5M
End of Life in the Very OldR01NR012459 · NINR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ALBERT, STEVEN M, LUNNEY, JUNE R · 2011 to 2015
$2.7M
Sarcopenia as a Predictor of Hospital-Associated Disability in Older AdultsK23AG058756 · NIA · UNIVERSITY OF WASHINGTON · PI ANDREWS, JAMES · 2018 to 2022
$1.6M
Mentored Patient Oriented Research in ARDS and Critical Illness OutcomesK24HL141526 · NHLBI · UNIVERSITY OF WASHINGTON · PI HOUGH, CATHERINE LEE · 2019 to 2023
$593k
Sarcopenia as a Predictor of Functional Outcomes of Acute Illness in Older Adults with DementiaR03AG063168 · NIA · UNIVERSITY OF WASHINGTON · PI ANDREWS, JAMES · 2019 to 2020
$311k
NHLBI NIH HHS K24 HL141526NIA NIH HHS K23 AG058756NIA NIH HHS P30 AG044281NIA NIH HHS R01 AG028050NIA NIH HHS R03 AG063168NINR NIH HHS R01 NR012459
6 · The paper itself

Abstract

backgroundIdentification of novel risk factors for dementia in older adults could facilitate development of methods to identify patients most at risk and improve their cognitive outcomes. We aimed to determine whether lower appendicular lean mass (ALM), assessed by dual-energy x-ray absorptiometry (DXA), and lower grip strength are associated with a greater likelihood of incident dementia among older adults in the Health Aging and Body Composition Study (Health ABC).

methodsHealth ABC data from 1997 to 2008 were analyzed (n = 2 704). Baseline ALM to body mass index (BMI) ratio (ALMBMI) was assessed by DXA. Baseline grip strength was assessed by hand-held dynamometry. Incident dementia diagnosis was defined as either (i) dementia-related hospitalization plus a Modified Mini-Mental State Examination (3MS) score of ≤ 90; or (ii) record of prescription for anti-dementia medication; or (iii) decline of at least 1.5 SDs on the 3MS score compared to baseline. Cox proportional hazard models estimated associations of ALMBMI and grip strength with incident dementia over follow-up with and without adjusting for covariates, stratified by sex.

resultsAmong older men, each standard deviation decrement in ALMBMI (adjusted hazard ratio [aHR]: 1.33; 95% confidence interval [CI]: 1.07, 1.65) or grip strength (aHR 1.22; 95% CI: 1.06, 1.41) was associated with increased likelihood of incident dementia.

conclusionsLower ALMBMI and grip strength may be important risk factors for the development of dementia among older men. How these factors may belong to a causal pathway of dementia must be elucidated in future work.

Indexed as

DementiaSarcopeniaAbsorptiometry, PhotonAgedAgingBody CompositionFemaleHand StrengthHumansIncidenceMaleBody compositionCognitionMuscleSex

Identifiers

PMID36548124
PMCPMC10613012

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.