Evidence map›Paper›PMID 36547933›Full record

ArticleMarine drugs2022

Polyphenolic Compounds Isolated from Marine Algae Attenuate the Replication of SARS-CoV-2 in the Host Cell through a Multi-Target Approach of 3CL

D P Nagahawatta, N M Liyanage, Jung-Geon Je, H H A C K Jayawardhana, Thilina U Jayawardena, Seong-Hun Jeong, Hyung-Jun Kwon, Cheol Soo Choi, You-Jin Jeon

Open access · goldAbstract read
In one paragraph

Article in Marine drugs, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Computational andFrontiers in pharmacology · 2025
    Article
  5. Review
  6. Review
  7. Article
  8. Review
  9. Fucoidan fromMarine drugs · 2023
    Article
  10. Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

D P NagahawattaDepartment of Marine Life Sciences, Jeju National University, Jeju 690-756, Republic of Korea.
N M LiyanageDepartment of Marine Life Sciences, Jeju National University, Jeju 690-756, Republic of Korea.
Jung-Geon JeDepartment of Marine Life Sciences, Jeju National University, Jeju 690-756, Republic of Korea.
H H A C K JayawardhanaDepartment of Marine Life Sciences, Jeju National University, Jeju 690-756, Republic of Korea.
Thilina U JayawardenaDepartment of Chemistry, Biochemistry and Physics, Université du Québec à Trois-Rivières, Trois-Rivières, QC G8Z 4M3, Canada.ORCID 0000-0002-4303-8282
Seong-Hun JeongFunctional Biomaterial Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 56212, Republic of Korea.ORCID 0000-0002-4611-7322
Hyung-Jun KwonFunctional Biomaterial Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 56212, Republic of Korea.
Cheol Soo ChoiKorea Mouse Metabolic Phenotyping Center, Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon 21999, Republic of Korea.
You-Jin JeonDepartment of Marine Life Sciences, Jeju National University, Jeju 690-756, Republic of Korea.ORCID 0000-0003-3299-7266
Jeju National University · KRKorea Research Institute of Bioscience and Biotechnology · KRGachon University · KRUniversité du Québec à Trois-Rivières · CA

Funding

Gachon University GCU-2019-0709Gachon University Gil Medical Center FRD2020-03
6 · The paper itself

Abstract

A global health concern has emerged as a response to the recent SARS-CoV-2 pandemic. The identification and inhibition of drug targets of SARS-CoV-2 is a decisive obligation of scientists. In addition to the cell entry mechanism, SARS-CoV-2 expresses a complicated replication mechanism that provides excellent drug targets. Papain-like protease (PL

Indexed as

Antiviral AgentsCOVID-19PolyphenolsSARS-CoV-2Virus ReplicationHumansMolecular Docking SimulationAntiviral AgentsPolyphenols3CLpromarine natural productmolecular dockingmulti-target approachPLproSARS-CoV-2

Identifiers

PMID36547933
PMCPMC9781010
OpenAlexW4312195005

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.