Evidence map›Paper›PMID 36547897›Full record

ArticleMarine drugs2022

A Single Amino Acid Replacement Boosts the Analgesic Activity of α-Conotoxin AuIB through the Inhibition of the GABA

Yuanmei Wei, Min Zhang, Shuo Yu, Qiuyuan Huang, Rongfang Chen, Shujing Xu, Yue Huang, Yunzhou Yu, Ming Liao, Qiuyun Dai

Open access · goldAbstract read
In one paragraph

Article in Marine drugs, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Yuanmei WeiBeijing Institute of Biotechnology, Beijing 100071, China.
Min ZhangBeijing Institute of Biotechnology, Beijing 100071, China.
Shuo YuBeijing Institute of Biotechnology, Beijing 100071, China.
Qiuyuan HuangBeijing Institute of Biotechnology, Beijing 100071, China.
Rongfang ChenBeijing Institute of Biotechnology, Beijing 100071, China.
Shujing XuBeijing Institute of Biotechnology, Beijing 100071, China.
Yue HuangBeijing Institute of Biotechnology, Beijing 100071, China.
Yunzhou YuBeijing Institute of Biotechnology, Beijing 100071, China.
Ming LiaoInstitute of Snake Venom, School of Basic Medical Sciences, Guangxi Medical University, Nanning 530021, China.
Qiuyun DaiBeijing Institute of Biotechnology, Beijing 100071, China.ORCID 0000-0003-2062-8332
Guangxi Medical University · CN

Funding

National Natural Science Foundation of China 81473192
6 · The paper itself

Abstract

α-conotoxin AuIB is the only one of the 4/6 type α-conotoxins (α-CTxs) that inhibits the γ-aminobutyric acid receptor B (GABA

Indexed as

ConotoxinsReceptors, NicotinicAmino AcidsAnalgesicsCalcium Channels, N-TypeDisulfidesgamma-Aminobutyric AcidAmino AcidsAnalgesicsCalcium Channels, N-Typeconotoxin AuIBConotoxinsDisulfidesgamma-Aminobutyric AcidReceptors, Nicotinicanalgesic activityGABABR-coupled CaV2.2structure–activity relationshipα-conotoxins AuIB

Identifiers

PMID36547897
PMCPMC9781320
OpenAlexW4310191691

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.