Evidence map›Paper›PMID 36547863›Full record

ArticleOphthalmology and therapy2023

Evaluation of Retinal Vascularity Index in Patients with COVID-19: A Case-Control Study.

Sandy Zhou Wenting, Ankita Shrivastav, Trupti Gilada, Xin Le Ng, Sean Ng, Chun Hau Chua, Shibjash Dutt, Sundaram Natarajan, Rupesh Agrawal

Open access · goldAbstract read
In one paragraph

Article in Ophthalmology and therapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Sandy Zhou WentingKhoo Teck Puat Hospital, Ophthalmology and Visual Science, National Health Group Eye Institute, Tan Tock Seng Hospital, Singapore, 308433, Singapore.
Ankita ShrivastavRadical Health, New Delhi, India.
Trupti GiladaMasina Hospital, Mumbai, India.
Xin Le NgDepartment of Ophthalmology, National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore, Singapore.
Sean NgLee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
Chun Hau ChuaDepartment of Ophthalmology, National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore, Singapore.
Shibjash DuttRadical Health, New Delhi, India.
Sundaram NatarajanAditya Jyot Eye Hospital, Mumbai, India.
Rupesh AgrawalDepartment of Ophthalmology, National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore, Singapore. Rupesh_agrawal@ttsh.com.sg.ORCID http://orcid.org/0000-0002-6662-5850
Tan Tock Seng Hospital · SGNanyang Technological University · SGAditya Jyot Eye Hospital · INBombay Hospital · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe purpose of this study was to evaluate the impact of COVID-19 infection on retinal microvasculature by topographically mapping the retinal arteriole-to-venule ratio (AVR).

methodsIn a comparative cross-sectional case-control study, fundus photos were obtained in COVID-19-infected patients and healthy controls. AVT was measured over 16 points across the retina using retinal vascularity index (RVI)-a novel semi-automated computerized parameter based on retinal vasculature.

resultsA total of 51 COVID-19-positive patients and 65 healthy controls were enrolled in the study. Overall, the mean RVI of all 16 points across the retina was 0.34 ± 0.02 in patients with COVID-19 and 0.33 ± 0.02 in control subjects (p = 0.64). Out of the 16 points being measured, three points had a statistically significant greater value in patients with COVID compared to normal controls.

conclusionLocalised greater RVI values were found in some of the points in COVID-19-positive patients, which likely indicates a more focal change of the vasculature.

Indexed as

Arteriole-to-venule ratioAVRChoroidCOVID-19Retinal vascularity indexRVI

Identifiers

PMID36547863
PMCPMC9774073
OpenAlexW4312080957

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.