Evidence map›Paper›PMID 36547848›Full record

ArticleMolecular neurobiology2023

Increased ATP Release and Higher Impact of Adenosine A

Francisco Q Gonçalves, Filipe C Matheus, Henrique B Silva, Joana I Real, Daniel Rial, Ricardo J Rodrigues, Jean-Pierre Oses, António C Silva, Nélio Gonçalves, Rui D Prediger and 2 more

Open access · hybridAbstract read
In one paragraph

Article in Molecular neurobiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 24 citations in OpenAlex.

  1. From danger to resolution: targeting purinergic signaling in CNS diseases.Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2026
    Review
  2. Review
  3. Article
  4. APurinergic signalling · 2026
    Article
  5. Endothelial adenosine AFrontiers in medicine · 2026
    Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Feedback facilitation by adenosine APurinergic signalling · 2024
    Article
  12. Adenosine AInternational journal of molecular sciences · 2024
    Article
  13. Article
  14. Review
  15. Review
  16. Adenosine ABiomolecules · 2023
    Article
  17. Adenosine ABiomolecules · 2023
    Article
  18. Lateral septum adenosine ANature communications · 2023
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Francisco Q GonçalvesCNC-Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.
Filipe C MatheusCNC-Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.
Henrique B SilvaCNC-Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.
Joana I RealCNC-Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.
Daniel RialCNC-Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.
Ricardo J RodriguesCNC-Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.
Jean-Pierre OsesCNC-Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.
António C SilvaCNC-Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.
Nélio GonçalvesCNC-Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.
Rui D PredigerDepartment of Pharmacology, Center of Biological Sciences, Federal University of Santa Catarina (UFSC), Florianópolis, SC, Brazil.
Ângelo R ToméCNC-Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.
Rodrigo A CunhaCNC-Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal. cunharod@gmail.com.ORCID http://orcid.org/0000-0003-2550-6422
University of Coimbra · PTUniversidade Federal de Santa Catarina · BR

Funding

FCT - Fundação para a Ciência e a Tecnologia POCI-01-0145-FEDER-03127FCT - Fundação para a Ciência e a Tecnologia UIDB/04539/2020Fundo Europeu de Desenvolvimento Regional CENTRO-01-0145-FEDER-000008:BrainHealth2020Fundo Europeu de Desenvolvimento Regional CENTRO-01-0246-FEDER-000010"la Caixa" Foundation LCF/PR/HP17/52190001
6 · The paper itself

Abstract

Extracellular ATP can be a danger signal, but its role in striatal circuits afflicted in Parkinson's disease (PD) is unclear and was now investigated. ATP was particularly released at high stimulation intensities from purified striatal nerve terminals of mice, which were endowed with different ATP-P2 receptors (P2R), although P2R antagonists did not alter corticostriatal transmission or plasticity. Instead, ATP was extracellularly catabolized into adenosine through CD73 to activate adenosine A

Indexed as

AdenosineParkinson DiseaseAdenosine TriphosphateAnimalsHumansLong-Term PotentiationMiceNeuronal PlasticityRatsAdenosineAdenosine TriphosphateA2A receptorsAdenosineATPEcto-5′-nucleotidaseParkinson’s disease

Identifiers

PMID36547848
PMCPMC9899190
OpenAlexW4312094048

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.