ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2023
Diagnostic value of heart-to-mediastinum ratio in
Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- American Society of Hematology 2026 guidelines on diagnosis of light chain amyloidosis.Blood advances · 2026Guideline
- Pathology-Based Validation of Quantitative SPECT/CT in Patients With Suspected Transthyretin Amyloid Cardiomyopathy.Circulation. Cardiovascular imaging · 2026Article
- Diagnostic and prognostic value ofEJNMMI reports · 2026Article
- Significance of regional myocardialThe international journal of cardiovascular imaging · 2026Article
- Nuclear Medicine Imaging for the Diagnosis of ATTR Cardiac Amyloidosis: Report of Japanese Society of Nuclear Cardiology Working Group.Annals of nuclear cardiology · 2025Review
- Lateral Planar Imaging ofAnnals of nuclear cardiology · 2024Article
- Cardiac Amyloidosis, Should We See It from the Side or the Front?Annals of nuclear cardiology · 2024Article
- Quantitative PYP metrics: separating the wheat from the chaff.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
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12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn transthyretin cardiac amyloidosis (ATTR-CA),
methodsWe retrospectively included 164 patients who underwent
resultsAfter the exclusion of patients who did not undergo endomyocardial biopsy, 30 patients (15 each with ATTR-CA and without ATTR-CA) were included. The receiver operating characteristic curve used to distinguish ATTR-CA from non-ATTR-CA patients revealed an area under the curve of 0.986 and 0.943, respectively. A H/M ratio of > 1.41 identified ATTR-CA patients with a sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of 100, 93.3, 93.3, and 100%, respectively. Conversely, an H/CL ratio of > 1.3 identified ATTR-CA patients with 100% sensitivity, 40.0% specificity, 62.5% PPV, and 100% NPV.
conclusionThe H/M ratio obtained at 3 hours post-injection has the potential to be a novel indicator for ATTR-CA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.