Evidence map›Paper›PMID 36547708›Full record

ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2023

Correlation of angiogenic growth factors and inflammatory cytokines with the clinical phenotype of ocular tuberculosis.

Aman Kumar, Ravinder Singh, Ravi Kumar Sharma, Surya Prakash Sharma, Aniruddha Agarwal, Vishali Gupta, Ramandeep Singh, Deeksha Katoch, Nirbhai Singh

Abstract read
PubMed Publisher
In one paragraph

Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Aman KumarAdvanced Eye Centre, Post Graduate Institute of Medical Education and Research, Sector-12, Chandigarh, India.
Ravinder SinghAdvanced Eye Centre, Post Graduate Institute of Medical Education and Research, Sector-12, Chandigarh, India.
Ravi Kumar SharmaAdvanced Eye Centre, Post Graduate Institute of Medical Education and Research, Sector-12, Chandigarh, India.
Surya Prakash SharmaAdvanced Eye Centre, Post Graduate Institute of Medical Education and Research, Sector-12, Chandigarh, India.
Aniruddha AgarwalAdvanced Eye Centre, Post Graduate Institute of Medical Education and Research, Sector-12, Chandigarh, India.
Vishali GuptaAdvanced Eye Centre, Post Graduate Institute of Medical Education and Research, Sector-12, Chandigarh, India.
Ramandeep SinghAdvanced Eye Centre, Post Graduate Institute of Medical Education and Research, Sector-12, Chandigarh, India.
Deeksha KatochAdvanced Eye Centre, Post Graduate Institute of Medical Education and Research, Sector-12, Chandigarh, India.
Nirbhai SinghAdvanced Eye Centre, Post Graduate Institute of Medical Education and Research, Sector-12, Chandigarh, India. nirbhais@gmail.com.ORCID http://orcid.org/0000-0002-5449-1330
Post Graduate Institute of Medical Education and Research · IN

Funding

Department of Biotechnology, Ministry of Science and Technology, India BT/PR13453/MED/30/1524/2015Indian Council of Medical Research 2015-1323 NCD II
6 · The paper itself

Abstract

purposeTo determine the correlation of angiogenic growth factors and inflammatory cytokines with the clinical phenotype of ocular tuberculosis (OTB).

methodsVitreous fluid was analysed for cytokines in patients with OTB and non-OTB uveitis using multiplex fluorescent bead-based flow cytometric assay. The clinical phenotypes were recorded and correlated with vitreous biomarkers.

resultsVitreous humour from OTB patients had elevated levels of interleukin-10 (IL-10), IL-17-A, interferon-gamma (IFN-γ), and tumour necrosis factor-alpha (TNF-α). Angiopoietin (Ang-2) levels were higher in the panuveitis phenotype. OTB posterior uveitis phenotype had relatively higher vascular endothelial growth factor (VEGF) levels and lower fibroblast growth factor (FGF) levels. Additionally, eyes with choroiditis and vasculitis had elevated levels of VEGF and Ang-2 with FGF downregulation. Both IFN-γ and IL-10 were upregulated in the choroiditis phenotype of OTB.

conclusionAngiogenic growth factors and inflammatory cytokines were altered in the vitreous humour of OTB patients. IFN-γ, VEGF, and IL-10 levels are increased in choroiditis and vasculitis phenotypes. Receiver operating characteristic (ROC) curve analysis further emphasized the importance of the IFN-γ assay in the diagnosis of OTB.

Indexed as

ChoroiditisTuberculosis, OcularCytokinesHumansIntercellular Signaling Peptides and ProteinsInterferon-gammaInterleukin-10PhenotypeVascular Endothelial Growth Factor ACytokinesIntercellular Signaling Peptides and ProteinsInterferon-gammaInterleukin-10Vascular Endothelial Growth Factor AAngiopoietinGrowth factorsInflammatory cytokinesOcular tuberculosisSerpiginous like choroiditisUveitis

Identifiers

PMID36547708
OpenAlexW4312094144

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.