Evidence map›Paper›PMID 36547658›Full record

ArticleJournal of functional morphology and kinesiology2022

Effects of Spinal Cord Injury Site on Cardiac Autonomic Regulation: Insight from Analysis of Cardiovascular Beat by Beat Variability during Sleep and Orthostatic Challenge.

Pietro Guaraldi, Mara Malacarne, Giorgio Barletta, Giuseppe De Scisciolo, Massimo Pagani, Pietro Cortelli, Daniela Lucini

Open access · goldAbstract read
In one paragraph

Article in Journal of functional morphology and kinesiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Special Issue "Role of Exercises in Musculoskeletal Disorders-5th Edition".Journal of functional morphology and kinesiology · 2025
    Article
  3. Recent updates in autonomic research: advances in the understanding of autonomic dysfunction after spinal cord injury.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Pietro GuaraldiIRCCS Istituto delle Scienze Neurologiche di Bologna, 40139 Bologna, Italy.ORCID 0000-0003-0597-603X
Mara MalacarneBIOMETRA Department, University of Milan, 20129 Milan, Italy.
Giorgio BarlettaDepartment of Biomedical and NeuroMotor Sciences (DiBiNeM), Alma Mater Studiorum-University of Bologna, 40123 Bologna, Italy.
Giuseppe De SciscioloNeurofisiopatologia, Azienda Ospedaliero-Universitaria Careggi, 50134 Firenze, Italy.
Massimo PaganiExercise Medicine Unit, Istituto Auxologico Italiano, IRCCS, 20135 Milan, Italy.
Pietro CortelliIRCCS Istituto delle Scienze Neurologiche di Bologna, 40139 Bologna, Italy.ORCID 0000-0002-3633-8818
Daniela LuciniBIOMETRA Department, University of Milan, 20129 Milan, Italy.ORCID 0000-0003-4845-8988
Istituto delle Scienze Neurologiche di Bologna · ITUniversity of Milan · ITAzienda Ospedaliero-Universitaria Careggi · ITIRCCS Istituto Auxologico Italiano · ITUniversity of Bologna · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe goal of this study on Spinal Cord Injury (SCI) patients with cervical or thoracic lesion was to assess whether disturbances of ANS control, according to location, might differently affect vagal and sympatho-vagal markers during sleep and orthostatic challenge. We analyzed with linear and nonlinear techniques beat-by-beat RR and arterial pressure (and respiration) variability signals, extracted from a polysomnographic study and a rest-tilt test. We considered spontaneous or induced sympathetic excitation, as obtained shifting from non-REM to REM sleep or from rest to passive tilt. We obtained evidence of ANS cardiac (dys)regulation, of greater importance for gradually proximal location (i.e., cervical) SCI, compatible with a progressive loss of modulatory role of sympathetic afferents to the spinal cord. Furthermore, in accordance with the dual, vagal and sympathetic bidirectional innervation, the results suggest that vagally mediated negative feedback baroreflexes were substantially maintained in all cases. Conversely, the LF and HF balance (expressed specifically by normalized units) appeared to be negatively affected by SCI, particularly in the case of cervical lesion (group

Indexed as

autonomic nervous systemsleep stagespectral analysisspinal cord injury sitesympathetic parasympathetic feedback

Identifiers

PMID36547658
PMCPMC9787160
OpenAlexW4312124149

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.