Evidence map›Paper›PMID 36547614›Full record

ArticleJournal of fungi (Basel, Switzerland)2022

Calcineurin Inhibitor CN585 Exhibits Off-Target Effects in the Human Fungal Pathogen

Praveen R Juvvadi, Benjamin G Bobay, D Christopher Cole, Monaf Awwa, William J Steinbach

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of fungi (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Praveen R JuvvadiDepartment of Pediatrics, Arkansas Children's Research Institute, University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA.
Benjamin G BobayDuke University NMR Center, Duke University Medical Center, Durham, NC 27710, USA.
D Christopher ColeDepartment of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA.ORCID 0000-0003-3087-7236
Monaf AwwaDepartment of Chemistry, Stony Brook University, Stony Brook, NY 11794, USA.
William J SteinbachDepartment of Pediatrics, Arkansas Children's Research Institute, University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA.
Arkansas Children's Hospital · USDuke Medical Center · USStony Brook University · US

Funding

Calcineurin regulatory network control of Aspergillus fumigatus hyphal septationR21AI163301 · NIAID · DUKE UNIVERSITY · PI JUVVADI, PRAVEEN RAO, STEINBACH, WILLIAM J · 2021 to 2022
$405k
National Institute of Allergy and Infectious Diseases R21AI163301NIAID NIH HHS R21 AI163301
6 · The paper itself

Abstract

Calcineurin (CN) is an attractive antifungal target as it is critical for growth, stress response, drug resistance, and virulence in fungal pathogens. The immunosuppressive drugs, tacrolimus (FK506) and cyclosporin A (CsA), are fungistatic and specifically inhibit CN through binding to their respective immunophilins, FK506-binding protein (FKBP12), and cyclophilin (CypA). We are focused on CN structure-based approaches for the development of non-immunosuppressive FK506 analogs as antifungal therapeutics. Here, we examined the effect of the novel CN inhibitor, CN585, on the growth of the human pathogen

Indexed as

AspergilluscalcineurinCN585cyclophilincyclosporin AFK506FKBP12molecular dockingmolecular dynamics

Identifiers

PMID36547614
PMCPMC9788591
OpenAlexW4311724413

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.