Evidence map›Paper›PMID 36547595›Full record

ReviewJournal of fungi (Basel, Switzerland)2022

Serum Beta-D-Glucan in the Diagnosis of Invasive Fungal Disease in Neonates, Children and Adolescents: A Critical Analysis of Current Data.

Laura Ferreras-Antolin, Andrew Borman, Antonia Diederichs, Adilia Warris, Thomas Lehrnbecher

Open access · goldAbstract readReview
In one paragraph

Review in Journal of fungi (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
1.9field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Brazilian guidelines for the diagnosis and treatment of candidemia and invasive candidiasis in adults and children.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases
    Guideline
  3. Review
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  5. Article
  6. Diagnosis ofInfection & chemotherapy · 2025
    Review
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  11. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Laura Ferreras-AntolinPaediatric Infectious Diseases and Immunology Unit, St George's University Hospitals NHS Foundation Trust, London SW17 0QT, UK.
Andrew BormanMedical Research Council Centre for Medical Mycology, University of Exeter, Exeter EX4 4QD, UK.ORCID 0000-0003-0585-5721
Antonia DiederichsDivision of Paediatric Haematology and Oncology, Hospital for Children and Adolescents, University Hospital Johann Wolfgang Goethe-University, 60323 Frankfurt am Main, Germany.
Adilia WarrisMedical Research Council Centre for Medical Mycology, University of Exeter, Exeter EX4 4QD, UK.ORCID 0000-0001-6586-3358
Thomas LehrnbecherDivision of Paediatric Haematology and Oncology, Hospital for Children and Adolescents, University Hospital Johann Wolfgang Goethe-University, 60323 Frankfurt am Main, Germany.ORCID 0000-0002-6022-3439
University of Exeter · GBGoethe University Frankfurt · DE

Funding

Medical Research Council MR/V033417/1
6 · The paper itself

Abstract

β-D-glucan (BDG) is a cell wall component of many pathogenic fungi. The detection of BDG as an assay is clinically broadly used as a diagnostic tool. However, the current data on BDG in paediatrics are limited, prompting specific considerations about when BDG can be used in neonates and children. We aimed to analyse the available data for the use of serum BDG in neonates and immunocompromised children and adolescents; as well as to understand the extent and characteristics of the use of BDG in children in Europe.

Indexed as

fungal diagnosticsinvasive fungal infections in childrenneonatal invasive candidiasisβ-D-glucan

Identifiers

PMID36547595
PMCPMC9783846
OpenAlexW4310387030

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.