Evidence map›Paper›PMID 36547533›Full record

ReviewJournal of functional biomaterials2022

Metal Oxide Nanoparticles: Review of Synthesis, Characterization and Biological Effects.

Andreea Mariana Negrescu, Manuela S Killian, Swathi N V Raghu, Patrik Schmuki, Anca Mazare, Anisoara Cimpean

Abstract readReview
In one paragraph

Review in Journal of functional biomaterials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed.

  1. Article
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  10. Review
  11. Article
  12. International journal of microbiology · 2026
    Article
  13. Article
  14. Review
  15. Review
  16. Synthesize of Tri-Metal Oxide MnOJournal of fluorescence · 2025
    Article
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Andreea Mariana NegrescuDepartment of Biochemistry and Molecular Biology, Faculty of Biology, University of Bucharest, 91-95 Splaiul Independentei, 050095 Bucharest, Romania.
Manuela S KillianDepartment of Chemistry and Biology, Chemistry and Structure of Novel Materials, University of Siegen, Paul-Bonatz-Str. 9-11, 57076 Siegen, Germany.ORCID 0000-0003-0892-4614
Swathi N V RaghuDepartment of Chemistry and Biology, Chemistry and Structure of Novel Materials, University of Siegen, Paul-Bonatz-Str. 9-11, 57076 Siegen, Germany.ORCID 0000-0001-8960-9581
Patrik SchmukiDepartment of Materials Science WW4-LKO, Friedrich-Alexander University, 91058 Erlangen, Germany.
Anca MazareDepartment of Materials Science WW4-LKO, Friedrich-Alexander University, 91058 Erlangen, Germany.ORCID 0000-0002-4836-946X
Anisoara CimpeanDepartment of Biochemistry and Molecular Biology, Faculty of Biology, University of Bucharest, 91-95 Splaiul Independentei, 050095 Bucharest, Romania.ORCID 0000-0002-5833-3110

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the last few years, the progress made in the field of nanotechnology has allowed researchers to develop and synthesize nanosized materials with unique physicochemical characteristics, suitable for various biomedical applications. Amongst these nanomaterials, metal oxide nanoparticles (MONPs) have gained increasing interest due to their excellent properties, which to a great extent differ from their bulk counterpart. However, despite such positive advantages, a substantial body of literature reports on their cytotoxic effects, which are directly correlated to the nanoparticles' physicochemical properties, therefore, better control over the synthetic parameters will not only lead to favorable surface characteristics but may also increase biocompatibility and consequently lower cytotoxicity. Taking into consideration the enormous biomedical potential of MONPs, the present review will discuss the most recent developments in this field referring mainly to synthesis methods, physical and chemical characterization and biological effects, including the pro-regenerative and antitumor potentials as well as antibacterial activity. Moreover, the last section of the review will tackle the pressing issue of the toxic effects of MONPs on various tissues/organs and cell lines.

Indexed as

antimicrobial activitycancer therapymetal oxide nanoparticlesnanotechnologynanotoxicitypro-regenerative potential

Identifiers

PMID36547533
PMCPMC9780975

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.