ArticleJournal of cardiovascular development and disease2022
Hemodynamic Analysis Shows High Wall Shear Stress Is Associated with Intraoperatively Observed Thin Wall Regions of Intracranial Aneurysms.
Article in Journal of cardiovascular development and disease, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Systematic Review of Radiomics and Artificial Intelligence in Intracranial Aneurysm Management.Journal of neuroimaging : official journal of the American Society of NeuroimagingPooled it
- From hemodynamic stress to inflammatory wall remodeling in intracranial aneurysms.Frontiers in molecular biosciences · 2026Review
- Intracranial Aneurysm Wall Phenotypes: Clinical, Morphological, and Hemodynamic Influences.Stroke (Hoboken, N.J.) · 2025Article
- Flow patterns inside the cerebral aneurysms affect aneurysm wall thickness.Neurosurgical review · 2025Observational
- Haemodynamic characteristics of thin-walled regions in intracranial aneurysms: intraoperative imaging and CFD analysis.Acta neurochirurgica · 2025Article
- Use of proper orthogonal decomposition and machine learning for efficient blood flow prediction in cerebral saccular aneurysms.Scientific reports · 2025Article
- Description of the local hemodynamic environment in intracranial aneurysm wall subdivisions.International journal for numerical methods in biomedical engineering · 2024Article
- Clinical and Hemodynamic Features of Aneurysm Rupture in Coil Embolization of Intracranial Aneurysms.Diagnostics (Basel, Switzerland) · 2024Article
- Nomogram-based geometric and hemodynamic parameters for predicting the growth of small untreated intracranial aneurysms.Neurosurgical review · 2024Article
- Computational Fluid Dynamic Simulations of Cerebral Aneurysms.Advances in experimental medicine and biology · 2024Review
- Four‑Dimensional Echocardiographic Evaluation of Cardiac Iron Overload in Patients with Beta-Thalassemia Major.Cardiovascular toxicology · 2024Observational
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
backgroundStudying the relationship between hemodynamics and local intracranial aneurysm (IA) pathobiology can help us understand the natural history of IA. We characterized the relationship between the IA wall appearance, using intraoperative imaging, and the hemodynamics from CFD simulations.
methodsThree-dimensional geometries of 15 IAs were constructed and used for CFD. Two-dimensional intraoperative images were subjected to wall classification using a machine learning approach, after which the wall type was mapped onto the 3D surface. IA wall regions included thick (white), normal (purple-crimson), and thin/translucent (red) regions. IA-wide and local statistical analyses were performed to assess the relationship between hemodynamics and wall type.
resultsThin regions of the IA sac had significantly higher WSS, Normalized WSS, WSS Divergence and Transverse WSS, compared to both normal and thick regions. Thicker regions tended to co-locate with significantly higher RRT than thin regions. These trends were observed on a local scale as well. Regression analysis showed a significant positive correlation between WSS and thin regions and a significant negative correlation between WSSD and thick regions.
conclusionHemodynamic simulation results were associated with the intraoperatively observed IA wall type. We consistently found that elevated WSS and WSS
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