Evidence map›Paper›PMID 36547416›Full record

ReviewJournal of cardiovascular development and disease2022

Comprehensive Review of Cardiovascular Disease Risk in Nonalcoholic Fatty Liver Disease.

Kevan Josloff, Jacob Beiriger, Adnan Khan, Richard J Gawel, Richard S Kirby, Aaron D Kendrick, Abhinav K Rao, Roy X Wang, Michelle M Schafer, Margaret E Pearce and 4 more

Open access · goldAbstract readReview
In one paragraph

Review in Journal of cardiovascular development and disease, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
4.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 30 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. MAFLD: Exploring the Systemic Effects Beyond Liver.Journal of community hospital internal medicine perspectives · 2025
    Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Kevan JosloffSidney Kimmel Medical College, Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA.
Jacob BeirigerSidney Kimmel Medical College, Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA.
Adnan KhanDepartment of Internal Medicine, Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA.
Richard J GawelSidney Kimmel Medical College, Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA.ORCID 0000-0003-0772-1559
Richard S KirbySidney Kimmel Medical College, Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA.
Aaron D KendrickSidney Kimmel Medical College, Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA.
Abhinav K RaoSidney Kimmel Medical College, Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA.
Roy X WangSidney Kimmel Medical College, Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA.ORCID 0000-0002-9244-1633
Michelle M SchaferSidney Kimmel Medical College, Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA.
Margaret E PearceSidney Kimmel Medical College, Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA.
Kashyap ChauhanDepartment of Internal Medicine, Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA.ORCID 0000-0002-1042-1568
Yash B ShahSidney Kimmel Medical College, Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA.
Gregary D MarhefkaDepartment of Internal Medicine, Division of Cardiology, Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA.
Dina Halegoua-DeMarzioDepartment of Internal Medicine, Division of Gastroenterology & Hepatology, Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA.ORCID 0000-0001-8298-5381
Thomas Jefferson University Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nonalcoholic Fatty Liver Disease (NAFLD) is a growing global phenomenon, and its damaging effects in terms of cardiovascular disease (CVD) risk are becoming more apparent. NAFLD is estimated to affect around one quarter of the world population and is often comorbid with other metabolic disorders including diabetes mellitus, hypertension, coronary artery disease, and metabolic syndrome. In this review, we examine the current evidence describing the many ways that NAFLD itself increases CVD risk. We also discuss the emerging and complex biochemical relationship between NAFLD and its common comorbid conditions, and how they coalesce to increase CVD risk. With NAFLD's rising prevalence and deleterious effects on the cardiovascular system, a complete understanding of the disease must be undertaken, as well as effective strategies to prevent and treat its common comorbid conditions.

Indexed as

CVDMAFLDNAFLD

Identifiers

PMID36547416
PMCPMC9786069
OpenAlexW4310188947

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.