Evidence map›Paper›PMID 36547309›Full record

ArticleGels (Basel, Switzerland)2022

Fabrication of High-Resolution Fine Microneedles Derived from Hydrolyzed Hyaluronic Acid Gels in Vacuum Environment Imprinting Using Water Permeable Mold.

Sayaka Miura, Rio Yamagishi, Riku Miyazaki, Kaori Yasuda, Yuki Kawano, Yoshiyuki Yokoyama, Naoto Sugino, Takao Kameda, Satoshi Takei

Open access · goldAbstract read
In one paragraph

Article in Gels (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Sayaka MiuraDepartment of Pharmaceutical Engineering, Toyama Prefectural University, Imizu, Toyama 939-0398, Japan.
Rio YamagishiDepartment of Pharmaceutical Engineering, Toyama Prefectural University, Imizu, Toyama 939-0398, Japan.
Riku MiyazakiDepartment of Pharmaceutical Engineering, Toyama Prefectural University, Imizu, Toyama 939-0398, Japan.
Kaori YasudaDepartment of Pharmaceutical Engineering, Toyama Prefectural University, Imizu, Toyama 939-0398, Japan.
Yuki KawanoToyama Industrial Technology Research and Development Center, Takaoka, Toyama 933-0981, Japan.
Yoshiyuki YokoyamaToyama Industrial Technology Research and Development Center, Takaoka, Toyama 933-0981, Japan.
Naoto SuginoFuturistic Technology Department, Sanko Gosei, Nanto, Toyama 939-1852, Japan.
Takao KamedaFuturistic Technology Department, Sanko Gosei, Nanto, Toyama 939-1852, Japan.
Satoshi TakeiDepartment of Pharmaceutical Engineering, Toyama Prefectural University, Imizu, Toyama 939-0398, Japan.ORCID 0000-0001-9285-692X
Toyama Prefectural University · JPToyama Industrial Technology Center · JP

Funding

Japan Science and Technology Agency JPMJTR192C
6 · The paper itself

Abstract

Hydrolyzed hyaluronic acid high-resolution fine microneedles of 13 µm in diameter and 24 µm in height were fabricated from hydrolyzed hyaluronic acid gels made in mixtures of water using vacuum environment imprint lithography processes with a water permeable mold. The gas traps of water and volatile solvents in the imprint materials cause transfer failure in the conventional water impermeable molds of quartz and metal. However, the water permeable mold allows the use of 67 wt% dilution water with high solubility to increase the fluidity of the hydrolyzed hyaluronic acid during the patterning of high-resolution fine microneedles for cosmetics and pharmaceuticals. This demonstration sets a new paradigm of functional pure gels for high-resolution nano-patterning applications with various cosmetic and pharmaceutical materials containing dilution water using a water permeable mold.

Indexed as

cosmeticsfine microneedlesfunctional gelshydrolyzed hyaluronic acidimprint lithographytransdermal drug delivery systemwater permeable mold

Identifiers

PMID36547309
PMCPMC9777786
OpenAlexW4310398616

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.