ArticleCurrent oncology (Toronto, Ont.)2022
Fatigue, Emotional Distress, and Illness Uncertainty in Patients with Metastatic Cancer: Results from the Prospective NEOETIC_SEOM Study.
Article in Current oncology (Toronto, Ont.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 5 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
49 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Prevalence, severity, and risk factors of cancer-related fatigue among working cancer survivors: a systematic review and meta-analysis.Journal of cancer survivorship : research and practice · 2025Pooled it
- Improving our understanding of the quality of life of patients with metastatic or recurrent/persistent anal cancer: a systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Pooled it
- Perioperative Trends in Distress Among Cancer Patients: A Systematic Review and Meta-Analysis.Cancer medicine · 2025Pooled it
- Pooled it
- The Relationship Between Illness Uncertainty and Social Support Among Cancer Patients: A Meta-analysis.Cancer nursingPooled it
- Narrative medicine in patients with cancer during intravenous antiblastic therapy: a qualitative study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Trial
- Psychometric properties of the Brief Mishel Uncertainty in illness scales for patients with advanced cancer and their family caregivers.BMC psychology · 2025Trial
- Post-diagnosis cannabis use and its association with health status and quality of life in cancer survivors.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- Supportive care needs among patients with breast and cervical cancer at a tertiary cancer treatment center in ethiopia: a cross-sectional study.Scientific reports · 2026Article
- Distress level in newly diagnosed thyroid cancer patients and predictors of clinically significant distress.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- Development and Validation of a Machine Learning-Based Prediction Model for Illness Uncertainty in Patients with Malignant Tumors.Healthcare (Basel, Switzerland) · 2026Article
- Dyadic Coping and Illness Uncertainty in Cancer Patient-Caregiver Dyads: Interactive Mechanisms, Heterogeneity, and Integrated Intervention Directions-A Narrative Review (2021-2025).Healthcare (Basel, Switzerland) · 2026Review
- Beyond image quality: Patient experience with long-axial field-of-view and standard PET/CT systems.European journal of nuclear medicine and molecular imaging · 2026Article
- Spanish adaptation and validation of Mishel's Uncertainty in Illness Scale (MUIS-A) in cancer patients.BMC psychology · 2026Article
- Impact of Physical Frailty on Early Intolerance to CAPOX Chemotherapy in Patients With Colon, Rectal, and Gastric Cancer.Cancer medicine · 2026Observational
- Association of family pharmacist continuity with patient-reported satisfaction in patients with metastatic cancer: a nationwide cross-sectional study.Journal of pharmaceutical health care and sciences · 2026Article
- Prevalence and determinants of sleep problems in cancer survivors compared to a normative population: a PROFILES registry study.Journal of cancer survivorship : research and practice · 2026Article
- Frailty and neuropathy in chemotherapy patients: moderated mediation roles of fatigue and mindfulness on CIPN, anxiety, and depression.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- Exploring perceptual disparities: A study on the level of understanding of colorectal cancer care among patients and healthcare professionals.International journal of colorectal disease · 2026Article
- Living Through Acute Helplessness and Ongoing Recovery: A Phenomenological Study of Patients with Guillain-Barré Syndrome Undergoing Therapeutic Plasma Exchange.Patient preference and adherence · 2026Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A cancer diagnosis can have a substantial impact on a patient's mental health and quality of life. The aim of this study was to investigate the prevalence of fatigue, emotional distress, and uncertainty and examine the predictive value they have on the quality of life of advanced cancer patients. A prospective, multicenter study was conducted between February 2020 and May 2021 of individuals diagnosed with an advanced, unresectable neoplasm prior to initiating systemic antineoplastic treatment. Participants completed questionnaires to quantify fatigue, emotional distress, disease uncertainty, and quality of life. A linear regression analysis was performed to study the predictive QoL variables. The study population comprised 508 patients, 53.7% of whom were male and had a mean age of 54.9 years. The most common cancers were digestive (40.6%), bronchopulmonary (29.1%), and breast (8.5%); the most frequent histology was adenocarcinoma (63%); and most were stage IV (79.7%). More than half (55.7%) suffered fatigue, and 47.7% exhibited emotional distress; both were more prevalent among women. Fatigue, emotional distress, and disease uncertainty all correlate with diminished quality of life. Similarly, ECOG performance status and the demographic variables of age, sex, and comorbidities impacted quality of life. This patient sample displayed a high prevalence of fatigue and emotional distress, together with illness uncertainty, which are clearly linked to waning quality of life. To decrease the experience of fatigue and improve mental health treatment in cancer patients, interventions based on a biopsychosocial model must be intensified.
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