Evidence map›Paper›PMID 36547073›Full record

ArticleCurrent issues in molecular biology2022

Regulatory Effects and Mechanism of Action of Green Tea Polyphenols on Osteogenesis and Adipogenesis in Human Adipose Tissue-Derived Stem Cells.

Weiguo Lao, Yi Zhao, Yi Tan, Michael Johnson, Yan Li, Linda Xiao, Jing Cheng, Yiguang Lin, Xianqin Qu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current issues in molecular biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Weiguo LaoSchool of Life Sciences, University of Technology Sydney, Ultimo, NSW 2007, Australia.
Yi ZhaoSchool of Life Sciences, University of Technology Sydney, Ultimo, NSW 2007, Australia.
Yi TanSchool of Life Sciences, University of Technology Sydney, Ultimo, NSW 2007, Australia.
Michael JohnsonSchool of Life Sciences, University of Technology Sydney, Ultimo, NSW 2007, Australia.
Yan LiSchool of Life Sciences, University of Technology Sydney, Ultimo, NSW 2007, Australia.
Linda XiaoSchool of Life Sciences, University of Technology Sydney, Ultimo, NSW 2007, Australia.
Jing ChengSchool of Life Sciences, University of Technology Sydney, Ultimo, NSW 2007, Australia.
Yiguang LinSchool of Life Sciences, University of Technology Sydney, Ultimo, NSW 2007, Australia.ORCID 0000-0002-4637-9701
Xianqin QuSchool of Life Sciences, University of Technology Sydney, Ultimo, NSW 2007, Australia.

Funding

Ministry of Science and Technology of the People's Republic of China (S2011GR0387)
6 · The paper itself

Abstract

We previously showed that green tea polyphenols (GTPs) exert antiadipogenic effects on preadipocyte proliferation. Here, we investigated the regulatory effects of GTPs on osteogenesis and adipogenesis during early differentiation of human adipose tissue-derived stem cells (hADSC). Adipogenesis of hADSCs was determined by oil-red-O staining and triglycerides synthesis measurement. Osteoporosis of hADSC was measured using alkaline phosphatase assays and intracellular calcium levels. Immunofluorescence staining and qRT-PCR were used to detect PPARγ-CEBPA regulated adipogenic pathway regulated by PPAR-CEBPA and the osteogenic pathway mediated by RUNX2-BMP2. We found that GTPs treatment significantly decreased lipid accumulation and cellular triglyceride synthesis in mature adipocytes and attenuated pioglitazone-induced adipogenesis in a dose-dependent manner. GTPs downregulated protein and mRNA expression of

Indexed as

adipogenesisgreen tea polyphenolshuman adipose tissue-derived stem cellsosteogenesisPPARγ-CEBPA signaling pathwayRUNX2-BMP2 pathway

Identifiers

PMID36547073
PMCPMC9776698

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.