ReviewDentistry journal2022
Effect of Endodontic Irrigating Solutions on Radicular Dentine Structure and Matrix Metalloproteinases-A Comprehensive Review.
Review in Dentistry journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 37 citations in OpenAlex.
- Effect of Active Oxygen Fluid (Blue®m) as a Root Canal Irrigant Against Enterococcus Faecalis.Oral health & preventive dentistry · 2024Trial
- Effect of dentin conditioners on biomarker release and microhardness of radicular dentin: an in vitro study.BMC oral health · 2026Article
- Long-Term Influence of Endodontic Irrigants on In Vitro Dentin Biomimetic Remineralization.Biomimetics (Basel, Switzerland) · 2026Article
- Effect of different irrigation regimen on sealability and push-out bond strength of biodentine when used for repair of furcal perforation in mandibular permanent molars: AnJournal of conservative dentistry and endodontics · 2026Article
- Dentin-preserving properties of cymbopogon nardus extract as a herbal endodontic irrigant againstJournal of conservative dentistry and endodontics · 2026Article
- Article
- Effects of three final irrigation solutions with chelation properties on the erosion and mineral content of root canal dentin.European oral research · 2026Article
- Does cleaning of post space before cementation of fiber reinforced post affect the push-out bond strength to resin cement?BMC oral health · 2025Article
- Comparative Antimicrobial and Oxidative Damage of Indocyanine Green, Methylene Blue, and Curcumin on Dual-Species Biofilms ofInternational journal of molecular sciences · 2025Article
- Effects of Various Chelating Agents in Combination with Sodium Hypochlorite on Root Fracture Toughness of Endodontically Treated Teeth after Ultrasonic Activation: AnJournal of pharmacy & bioallied sciences · 2025Article
- The impact of maleic acid, carbohydrate-derived fulvic acid, and ethylenediaminetetraacetic acid on the flexural strength and modulus of elasticity of human radicular dentin: an in vitro study.European oral research · 2025Article
- Evaluation of the Cleanliness and Sealer Penetration of the Root Canal System Following Final Irrigation Using Chelating Agents.European endodontic journal · 2025Article
- Comparative Evaluation of the Effect of EDTA, Chitosan, Etidronic Acid, and Silver Citrate on the Mineral Content of Root Canal Dentin Using Energy Dispersive X-ray Spectroscopy: An In-Vitro Study.European endodontic journal · 2025Article
- Effect of Final Irrigation Solutions on Mechanical Properties of Root Canal Dentine Running title: Final Irrigation on Mechanical Properties.European endodontic journal · 2024Article
- Evaluation of the Effect of Chitosan-Based Irrigation Solutions on the Bond Strength of Mineral Trioxide Aggregate to Bulk-Fill Composite.Journal of functional biomaterials · 2024Article
- Role of Metalloproteinases in Adhesion to Radicular Dentin: A Literature Review.Materials (Basel, Switzerland) · 2024Review
- The Impact of Different Irrigation Protocols on the Bond Strength of Self-Adhesive Resin Cement to Radicular Dentin.Acta stomatologica Croatica · 2024Article
- New Insights Regarding the Use of Relevant Synthetic Compounds in Dentistry.Molecules (Basel, Switzerland) · 2024Review
- Cytotoxic Effect of Two Different Concentrations of Sodium Hypochlorite: An In-Vitro Study.Cureus · 2024Article
- Impact of using XP-endo finisher and nanobubble water during EDTA dentin conditioning on TGF-β1 release in regenerative endodontic procedures.BMC oral health · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Irrigating solutions play an important role in the eradication of intracanal microbes and debris dissolution during endodontic treatment. Different combinations of solutions and protocols have been advocated, with sodium hypochlorite (NaOCl), ethylenediamine tetra acetic acid (EDTA), and chlorhexidine (CHX) remaining the most widely used ones by many clinicians. Although these solutions provide efficient inorganic dissolution and antimicrobial capacity, their use has also been reported to cause undesired effects on root dentin composition and mechanical and biomechanical properties, such as microhardness, surface roughness, bond strength, and matrix metalloproteinase (MMP) activity. Several corroborating studies attribute these changes in mechanical properties of dentine to the use of irrigating solutions, and there are limited reports on how the solutions affect the expression of MMPs, which may be a correlating link to understanding the role of these enzymes in dentin collagen and changes in the mechanical properties of dentin. Hence, using the basis of several studies from the literature, the objective is to comprehensively review the influence of individual and combined irrigating solutions on root dentine structure and the activity of the MMPs.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.