ArticleNucleic acids research2023
DNA-TCP complex structures reveal a unique recognition mechanism for TCP transcription factor families.
Article in Nucleic acids research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 23 citations in OpenAlex.
- Genome-Wide Identification and Comparative Analysis of the TCP Transcription Factor Family in ThreeInternational journal of molecular sciences · 2026Article
- Non-triazine photosystem II inhibitors provide effective control of metabolic atrazine-resistant Amaranthus tuberculatus.Pest management science · 2026Article
- TCP21 negatively regulates photomorphogenesis by integrating phyB- and HY5-mediated signaling pathways in Arabidopsis.The Plant journal : for cell and molecular biology · 2026Article
- Evolution of the TCP gene family and pan-genome analysis in tea (Camellia sinensis).BMC plant biology · 2026Article
- 'Candidatus Liberibacter Asiaticus' Effector SECP8 Subverts Salicylic Acid-Mediated Citrus Immunity via a Two-Pronged Impairment of CsTCP15 Dimerization.Plant biotechnology journal · 2026Article
- Expression of the quinoaFrontiers in plant science · 2026Article
- Effector innovation in genome-reduced phytoplasmas and other host-dependent mollicutes.PLoS genetics · 2025Article
- TCP3 is a substrate of the COP1/SPA ubiquitin ligase to regulate anthocyanin accumulation and flowering time inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Genome-wide analysis of TCP family genes and their constitutive expression pattern analysis in the melon (Cucumis melo).Genes & genomics · 2025Article
- Genome-wide analysis and expression profile of3 Biotech · 2024Article
- Class I TCP in fruit development: much more than growth.Frontiers in plant science · 2024Review
- Genome-Wide Identification of TCP Gene Family inInternational journal of molecular sciences · 2023Article
- TCP Transcription Factors in Plant Reproductive Development: Juggling Multiple Roles.Biomolecules · 2023Review
- Physiological Roles and Mechanisms of Action of Class I TCP Transcription Factors.International journal of molecular sciences · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plant-specific TCP transcription factors are key regulators of diverse plant functions. TCP transcription factors have long been annotated as basic helix-loop-helix (bHLH) transcription factors according to remote sequence homology without experimental validation, and their consensus DNA-binding sequences and protein-DNA recognition mechanisms have remained elusive. Here, we report the crystal structures of the class I TCP domain from AtTCP15 and the class II TCP domain from AtTCP10 in complex with different double-stranded DNA (dsDNA). The complex structures reveal that the TCP domain is a distinct DNA-binding motif and the homodimeric TCP domains adopt a unique three-site recognition mode, binding to dsDNA mainly through a central pair of β-strands formed by the dimer interface and two basic flexible loops from each monomer. The consensus DNA-binding sequence for class I TCPs is a perfectly palindromic 11 bp (GTGGGNCCCAC), whereas that for class II TCPs is a near-palindromic 11 bp (GTGGTCCCCAC). The unique DNA binding mode allows the TCP domains to display broad specificity for a range of DNA sequences even shorter than 11 bp, adding further complexity to the regulatory network of plant TCP transcription factors.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.