Evidence map›Paper›PMID 36546648›Full record

ArticleCartilage2023

CCN4/WISP1 Promotes Migration of Human Primary Osteoarthritic Chondrocytes.

Ritchie G M Timmermans, Arjen B Blom, Niek G C Bloks, Rob G H H Nelissen, Enrike H M J van der Linden, Peter M van der Kraan, Ingrid Meulenbelt, Yolande F M Ramos, Martijn H J van den Bosch

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cartilage, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Comprehensive Profiling of NAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  2. Review
  3. An overview of CCN4 (WISP1) role in human diseases.Journal of translational medicine · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Ritchie G M TimmermansExperimental Rheumatology, Radboud university medical center, Nijmegen, The Netherlands.ORCID 0000-0002-0787-0856
Arjen B BlomExperimental Rheumatology, Radboud university medical center, Nijmegen, The Netherlands.
Niek G C BloksSection Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Centre, Leiden, The Netherlands.
Rob G H H NelissenDepartment of Orthopaedics, Leiden University Medical Centre, Leiden, The Netherlands.
Enrike H M J van der LindenDepartment of Orthopaedics, Leiden University Medical Centre, Leiden, The Netherlands.
Peter M van der KraanExperimental Rheumatology, Radboud university medical center, Nijmegen, The Netherlands.
Ingrid MeulenbeltSection Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Centre, Leiden, The Netherlands.
Yolande F M RamosSection Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Centre, Leiden, The Netherlands.ORCID 0000-0003-1459-413X
Martijn H J van den BoschExperimental Rheumatology, Radboud university medical center, Nijmegen, The Netherlands.
Leiden University Medical Center · NLRadboud University Nijmegen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesPreviously, we have shown the involvement of cellular communication network factor 4/Wnt-activated protein Wnt-1-induced signaling protein 1 (CCN4/WISP1) in osteoarthritic (OA) cartilage and its detrimental effects on cartilage. Here, we investigated characteristics of CCN4 in chondrocyte biology by exploring correlations of CCN4 with genes expressed in human OA cartilage with functional follow-up.

designSpearman correlation analysis was performed for genes correlating with

resultsCorrelation of

conclusionCCN4 increases cell migration of human primary OA chondrocytes. Since WISP1 expression is known to be increased in OA cartilage, this may serve to direct chondrocytes toward cartilage defects and orchestrate repair.

Indexed as

Cartilage, ArticularChondrocytesCell DifferentiationCells, CulturedHumansSignal TransductioncartilageCCN4/WISP1chondrocytemigrationosteoarthritis

Identifiers

PMID36546648
PMCPMC10076902
OpenAlexW4312094881

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.