Evidence map›Paper›PMID 36546402›Full record

Trial reportJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2023

Association between psychotropic medication and sleep microstructure: evidence from large population studies.

Simon Hartmann, Liborio Parrino, Kristine Ensrud, Katie L Stone, Susan Redline, Scott R Clark, Mathias Baumert

Registry-linked trialOpen access · bronzeAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00070681 (Outcomes of Sleep Disorders in Older Men), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00070681 completednot on this map

Outcomes of Sleep Disorders in Older Men

TypeobservationalSponsorNational Heart, Lung, and Blood Institute (NHLBI)Ran2003 to 2007ConditionsCardiovascular Diseases, Heart Diseases, Sleep, Sleep Apnea SyndromesArmsPolysomnography
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 3 countries.

Simon HartmannThe University of Adelaide, School of Electrical and Electronic Engineering, Adelaide, South Australia, Australia.
Liborio ParrinoSleep Disorders Center, Department of Neurology, University of Parma, Parma, Emilia-Romagna, Italy.
Kristine EnsrudCenter for Chronic Disease Outcomes Research, Veterans Affairs Medical Center, Minneapolis, Minnesota.
Katie L StoneCalifornia Pacific Medical Center Research Institute, San Francisco, California.
Susan RedlineDepartments of Medicine and Neurology, Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Scott R ClarkThe University of Adelaide, Discipline of Psychiatry, Adelaide Medical School, Adelaide, South Australia, Australia.
Mathias BaumertThe University of Adelaide, School of Electrical and Electronic Engineering, Adelaide, South Australia, Australia.
University of Adelaide · AUCalifornia Pacific Medical Center · USHarvard University · USUniversity of Parma · ITVeterans Health Administration · US

Funding

Study of Osteoporotic FracturesR01AG005407 · NIA · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI CUMMINGS, STEVEN RON, YAFFE, KRISTINE · 1986 to 2016
$23.2M
Outcomes of Sleep Disorders in Older MenR01HL071194 · NHLBI · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI STONE, KATIE L · 2003 to 2013
$12.2M
Changes in Sleep and Cognition in Older WomenR01AG026720 · NIA · CALIFORNIA PACIFIC MED CTR RES INSTITUTE · PI STONE, KATIE L, YAFFE, KRISTINE · 2006 to 2016
$7.5M
Study of Osteoporotic FracturesR01AG005394 · NIA · UNIVERSITY OF MINNESOTA TWIN CITIES · PI ENSRUD, KRISTINE · 1986 to 2015
$6.1M
STUDY OF OSTEOPOROTIC FRACTURES: VERTEBRAL FRACTURESR01AR035583 · NIAMS · KAISER FOUNDATION RESEARCH INSTITUTE · PI HILLIER, TERESA A · 1986 to 2005
$3.2M
Study of Osteoporotic Fractures (SOF)R01AG027574 · NIA · KAISER FOUNDATION RESEARCH INSTITUTE · PI HILLIER, TERESA A · 2006 to 2015
$2.6M
Study of Osteoporotic Fractures (SOF)-Pittsburgh ClinicR01AG027576 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CAULEY, JANE ANN · 2006 to 2015
$2.4M
Study of Osteoporotic FracturesR01AR035582 · NIAMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CAULEY, JANE · 1986 to 2005
$2.4M
Study of Osteoporotic FracturesR01AR035584 · NIAMS · UNIVERSITY OF MARYLAND BALTIMORE · PI HOCHBERG, MARC C. · 1986 to 2005
$2.1M
Outcomes of Sleep Disorders in Older Men-PortlandR01HL070838 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI ORWOLL, ERIC S. · 2003 to 2007
$1.8M
Outcomes of Sleep Disorders in Older MenR01HL070848 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BARRETT-CONNOR, ELIZABETH L · 2003 to 2007
$1.6M
Outcomes of Sleep Disorders in Older Men-Palo AltoR01HL070841 · NHLBI · STANFORD UNIVERSITY · PI STEFANICK, MARCIA L · 2003 to 2007
$1.4M
NHLBI NIH HHS R01 HL070837NHLBI NIH HHS R01 HL070838NHLBI NIH HHS R01 HL070839NHLBI NIH HHS R01 HL070841NHLBI NIH HHS R01 HL070842NHLBI NIH HHS R01 HL070847NHLBI NIH HHS R01 HL070848NHLBI NIH HHS R01 HL071194NIAMS NIH HHS R01 AR035582NIAMS NIH HHS R01 AR035583NIAMS NIH HHS R01 AR035584NIA NIH HHS R01 AG005394NIA NIH HHS R01 AG005407NIA NIH HHS R01 AG026720NIA NIH HHS R01 AG027574NIA NIH HHS R01 AG027576
6 · The paper itself

Abstract

STUDY

objectivesTo assess the association between psychotropic medications and sleep microstructure in large community-based cohorts of older people.

methodsWe analyzed overnight polysomnograms of 381 women from the Study of Osteoporotic Fractures (SOF) and 2,657 men from the Osteoporotic Fractures in Men Sleep Study (MrOS), who either used no psychotropic medication (n = 2,819), only benzodiazepines (n = 112), or only selective serotonin reuptake inhibitors (SSRI) (n = 107). Sleep microstructure (cyclic alternating pattern, CAP) was compared between the no medication group and psychotropic medication groups using the Mann-Whitney

resultsCAP rate, arousal index, apnea-hypopnea index, and the frequency of slow, low-amplitude electroencephalography activation phases were significantly lower in MrOS participants using benzodiazepines than participants not taking psychotropic medication. SSRI users in MrOS experienced no altered sleep microstructure compared to those with no psychotropic use. SOF participants using benzodiazepines did not show similar associations with sleep microstructure. However, SSRI users from SOF had a significantly higher frequency of rapid, high-amplitude electroencephalography activation phases (A2 + 3) and periodic limb-movement index than participants not taking psychotropic medication. Multivariable linear regression adjusted for demographic, lifestyle, mood disorders, and health variables indicated additional significant associations between benzodiazepine usage and CAP rate and A2 + 3 index, respectively, in older men, and between CAP rate and SSRI usage in older women.

conclusionsWe identified significant associations between sleep microstructure and psychotropic drugs in MrOS and SOF, highlighting the importance of comprehensive sleep analysis, including CAP. Our results may improve understanding of the differences in sleep-wake mechanisms based on psychotropic usage. CLINICAL

trial registrationRegistry: ClinicalTrials.gov; Title: Outcomes of Sleep Disorders in Older Men; Identifier: NCT00070681; URL: https://clinicaltrials.gov/ct2/show/record/NCT00070681. CITATION: Hartmann S, Parrino L, Ensrud K, et al. Association between psychotropic medication and sleep microstructure: evidence from large population studies.

Indexed as

Osteoporotic FracturesAgedBenzodiazepinesFemaleHumansMalePolysomnographyPsychotropic DrugsSleepBenzodiazepinesPsychotropic Drugsbenzodiazepinescyclic alternating patternselective serotonin reuptake inhibitorssleep studiessleep-wake mechanisms

Identifiers

PMID36546402
PMCPMC9978436
OpenAlexW4312094217

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.