Evidence map›Paper›PMID 36545918›Full record

ArticleMultiple sclerosis (Houndmills, Basingstoke, England)2023

Magnetization transfer saturation reveals subclinical optic nerve injury in pediatric-onset multiple sclerosis.

Giulia Longoni, Edgar Martinez Chavez, Kimberly Young, Robert A Brown, Sonya Bells, Dumitru Fetco, Laura Kim, Stephanie A Grover, Fiona Costello, Arun Reginald and 9 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Multiple sclerosis (Houndmills, Basingstoke, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 7 institutions in 2 countries.

Giulia LongoniDivision of Neurology, Department of Pediatrics, University of Toronto, Toronto, ON, Canada/Department of Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, ON, Canada.
Edgar Martinez ChavezDepartment of Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, ON, Canada.
Kimberly YoungDivision of Neurology, Department of Pediatrics, University of Toronto, Toronto, ON, Canada.
Robert A BrownShadowLab Research Inc., Toronto, ON, Canada.
Sonya BellsDepartment of Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, ON, Canada.ORCID 0000-0001-8688-1571
Dumitru FetcoMcConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada.ORCID 0000-0003-1335-8274
Laura KimDepartment of Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, ON, Canada.
Stephanie A GroverDivision of Neurology, Department of Pediatrics, University of Toronto, Toronto, ON, Canada.
Fiona CostelloDepartments of Clinical Neurosciences and Surgery, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.ORCID 0000-0001-8007-6627
Arun ReginaldDepartment of Ophthalmology and Visual Sciences, The University of Toronto, Toronto, ON, Canada.
Amit Bar-OrDepartment of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Ruth Ann MarrieDepartments of Internal Medicine and Community Health Sciences, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada.ORCID 0000-0002-1855-5595
Douglas L ArnoldMcConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada/Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada.ORCID 0000-0003-4266-0106
Sridar NarayananMcConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada.
Helen M BransonDepartment of Diagnostic Imaging, University of Toronto, Toronto, ON, Canada.
Brenda L BanwellDivision of Neurology, The Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
John G SledDepartment of Medical Biophysics, University of Toronto, Toronto, ON, Canada.
Donald J MabbottDepartment of Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, ON, Canada.
E Ann YehDivision of Neurology, Department of Pediatrics, University of Toronto, Toronto, ON, Canada/Department of Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, ON, Canada.ORCID 0000-0002-5393-7417
University of Toronto · CAHospital for Sick Children · CAMontreal Neurological Institute and Hospital · CAChildren's Hospital of Philadelphia · USUniversity of Calgary · CAUniversity of Manitoba · CAUniversity of Pennsylvania · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe presence of subclinical optic nerve (ON) injury in youth living with pediatric-onset MS has not been fully elucidated. Magnetization transfer saturation (MTsat) is an advanced magnetic resonance imaging (MRI) parameter sensitive to myelin density and microstructural integrity, which can be applied to the study of the ON.

objectiveThe objective of this study was to investigate the presence of subclinical ON abnormalities in pediatric-onset MS by means of magnetization transfer saturation and evaluate their association with other structural and functional parameters of visual pathway integrity.

methodsEleven youth living with pediatric-onset MS (ylPOMS) and no previous history of optic neuritis and 18 controls underwent standardized brain MRI, optical coherence tomography (OCT), Magnetoencephalography (MEG)-Visual Evoked Potentials (VEPs), and visual battery. Data were analyzed with mixed effect models.

resultsWhile ON volume, OCT parameters, occipital MEG-VEPs outcomes, and visual function did not differ significantly between ylPOMS and controls, ylPOMS had lower MTsat in the supratentorial normal appearing white matter (-0.26 nU,

conclusionsSubclinical microstructural injury affects the ON of ylPOMS. This may appear as MTsat changes before being detectable by other currently available testing.

Indexed as

Multiple SclerosisOptic Nerve InjuriesOptic NeuritisAdolescentChildEvoked Potentials, VisualHumansMagnetic Resonance ImagingOptic NerveTomography, Optical Coherencemagnetization transferoptical coherence tomographyoptic nervePediatric MSquantitative MRIvisual functions

Identifiers

PMID36545918
PMCPMC9925884
OpenAlexW4312095631

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.