ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2023
Cerebral blood flow regulates iron overload in the cerebral nuclei of hemodialysis patients with anemia.
Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed, 11 citations in OpenAlex.
- Regulation of brain iron homeostasis and its influence on cognitive function.European radiology · 2026Article
- Exploring the role of quantitative susceptibility mapping in assessing brain iron deposition in hemodialysis patients.Insights into imaging · 2026Article
- Association between deep gray matter iron deposition, white matter hyperintensity, and hypertensive cognitive impairment.Quantitative imaging in medicine and surgery · 2025Article
- Regional high iron deposition on brain quantitative susceptibility mapping correlates with cognitive decline in chronic kidney disease patients.Brain imaging and behavior · 2025Article
- Blunted cerebral hemodynamic responses to incremental exercise in patients with end-stage renal disease.International urology and nephrology · 2024Article
- The effect of post-labeling delay on cerebral blood flow is influenced by age and sex: a study based on arterial spin-labeling magnetic resonance imaging.Quantitative imaging in medicine and surgery · 2024Article
- Multiparameter neuroimaging study of neurovascular coupling changes in patients with end-stage renal disease.Brain and behavior · 2024Article
- The covariant structural and functional neuro-correlates of cognitive impairments in patients with end-stage renal diseases.Frontiers in neuroscience · 2024Article
- Deep gray matters iron deposition is positively associated with white matter hyperintensity in hypertension.Journal of clinical hypertension (Greenwich, Conn.) · 2023Article
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Authors and funding
12 authors at 3 institutions in 1 country.
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Abstract
Hemodialysis patients exhibit anemia-related cerebral hyperperfusion and iron deposition (ID). However, the mechanisms underlying the pathology of cerebral ID are not clear. We investigated the role of cerebral blood flow (CBF) in the pathophysiology of cerebral ID in hemodialysis patients with anemia. This study recruited 33 hemodialysis patients with anemia and thirty-three healthy controls (HCs). All the subjects underwent quantitative susceptibility mapping (QSM) and arterial spin labeling (ASL) to measure ID and CBF in the cerebral nuclei. Furthermore, we evaluated lacunar infarction (LI), cerebral microbleeds, and total white matter hyperintensity volume (TWMHV). Hemodialysis patients with anemia showed significantly higher ID and CBF in some nuclei compared to the HCs after adjusting for age, sex, and total intracranial volume (TIV) [
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