Evidence map›Paper›PMID 36545548›Full record

ArticleInternational medical case reports journal2022

Clinical Course of Two Patients with COVID-19 Respiratory Failure After Administration of the Anticancer Small Molecule, RRx-001.

Terese Catherine Hammond, Raymond C Lee, Bryan Oronsky, Tony R Reid, Scott Caroen, Tiffany M Juarez, Jaya Gill, Annie Heng, Santosh Kesari

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in International medical case reports journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Terese Catherine HammondProvidence St. Johns Health Center, Santa Monica, CA, USA.
Raymond C LeeProvidence St. Johns Health Center, Santa Monica, CA, USA.
Bryan OronskyEpicentRx, Inc., La Jolla, CA, USA.ORCID 0000-0002-3940-6329
Tony R ReidEpicentRx, Inc., La Jolla, CA, USA.
Scott CaroenEpicentRx, Inc., La Jolla, CA, USA.
Tiffany M JuarezJohn Wayne Cancer Institute, Santa Monica, CA, USA.
Jaya GillPacific Neuroscience Institute, Santa Monica, CA, USA.
Annie HengJohn Wayne Cancer Institute, Santa Monica, CA, USA.
Santosh KesariProvidence St. Johns Health Center, Santa Monica, CA, USA.ORCID 0000-0003-3772-6000

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Two critically ill COVID-19 infected patients, who had exhausted all available treatment options, were treated with the small-molecule RRx-001 with subsequent improvement. RRx-001, a first-in-class small molecule with anti-inflammatory, vascular normalizing and macrophage-repolarizing properties, has been safely administered 300+ patients in clinical trials. This is the first report of RRx-001 treatment of COVID-19.

Indexed as

ARDSCOVID-19critical carenitric oxideRRx-001SARS-CoV-2viral diseases

Identifiers

PMID36545548
PMCPMC9762260

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.