ReviewChemical science2022
Recent advances in the dearomative functionalisation of heteroarenes.
Review in Chemical science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Photoinduced Hydrogenative Dearomatization With Homocoupling of Quinolines to Construct Octahydro-4,4'-biquinolines.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Article
- Three-Way Chemodivergent Derivatization of Non-Activated 2-Arylphenyl Benzyl Ethers.The Journal of organic chemistry · 2025Article
- Reimagining Dearomatization: Arenophile-Mediated Single-Atom Insertions and π-Extensions.Accounts of chemical research · 2025Article
- Reductive Transamination of Pyridinium Salts to N-Aryl Piperidines.The Journal of organic chemistry · 2024Article
- Photochemical dearomative skeletal modifications of heteroaromatics.Chemical Society reviews · 2024Review
- Chemoselective Diazine Dearomatization: The Catalytic Enantioselective Dearomatization of Pyrazine.Journal of the American Chemical Society · 2024Article
- Oxidative Dearomatization of Pyridines.Journal of the American Chemical Society · 2024Article
- Photochemical Reduction of Quinolines with γ-Terpinene.Organic letters · 2024Article
- Rhodium-Catalyzed Asymmetric Functionalization of Quinoxalinium Salts.Organic letters · 2023Article
- Catalytic Enantioselective Synthesis of 3-Piperidines from Arylboronic Acids and Pyridine.Journal of the American Chemical Society · 2023Article
- Catalyst-Controlled Enantioselective and Regiodivergent Addition of Aryl Boron Nucleophiles to N-Alkyl Nicotinate Salts.Journal of the American Chemical Society · 2023Article
- Dearomative intermolecular [2 + 2] photocycloaddition for construction of C(spChemical science · 2023Article
- Synthesis of Dihydropyridine Spirocycles by Semi-Pinacol-Driven Dearomatization of Pyridines.Organic letters · 2023Article
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Authors and funding
3 authors.
Funding
Abstract
Dearomatisation reactions of (hetero)arenes have been widely employed as efficient methods to obtain highly substituted saturated cyclic compounds for over a century. In recent years, research in this area has shifted towards effecting additional C-C bond formation during the overall dearomative process. Moving away from classical hydrogenation-based strategies a wide range of reagents were found to be capable of initiating dearomatisation through nucleophilic addition (typically a reduction) or photochemically induced radical addition. The dearomatisation process gives rise to reactive intermediates which can be intercepted in an intra- or intermolecular fashion to deliver products with significantly increased molecular complexity when compared to simple dearomatisation. In this Perspective recent examples and strategies for the dearomative functionalisation of heteroaromatic systems will be discussed.
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Registered trials
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