Metal-free hydrosulfonylation of α,β-unsaturated ketones: synthesis and application of γ-keto sulfones.

Xiufang Cheng, Shuo Wang, Yibo Wei, Huamin Wang, Ying-Wu Lin

Abstract read

In one paragraph

Article in RSC advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

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Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Modular, Tricomponent, and Concurrent One-Pot Synthesis of Libraries of γ-Keto Sulfones and γ-Keto Phosphine Oxides using Brønsted Acidic Eutectic Mixtures.ChemSusChem · 2025
Article

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5 · Who and what money

Authors and funding

5 authors.

Xiufang ChengSchool of Chemistry and Chemical Engineering, University of South China Hengyang P. R. China huaminwang@usc.edu.cn linlinying@hotmail.com.

Shuo WangSchool of Chemistry and Chemical Engineering, University of South China Hengyang P. R. China huaminwang@usc.edu.cn linlinying@hotmail.com.

Yibo WeiSchool of Chemistry and Chemical Engineering, University of South China Hengyang P. R. China huaminwang@usc.edu.cn linlinying@hotmail.com.

Huamin WangSchool of Chemistry and Chemical Engineering, University of South China Hengyang P. R. China huaminwang@usc.edu.cn linlinying@hotmail.com.ORCID https://orcid.org/0000-0002-4844-8766

Ying-Wu LinSchool of Chemistry and Chemical Engineering, University of South China Hengyang P. R. China huaminwang@usc.edu.cn linlinying@hotmail.com.ORCID https://orcid.org/0000-0002-2457-0871

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

γ-Keto sulfones are versatile building blocks and valuable intermediates in organic synthesis and pharmaceutical chemistry. Motivated by their excellent properties, we herein report a green, convenient, metal-free hydrosulfonylation method for a variety of ynones, vinyl ketones, and sodium sulfinates in the absence of stoichiometric oxidants. This operationally simple protocol provides straightforward and practical access to a wide range of γ-keto sulfones with broad functional group tolerance from easily available starting materials. Moreover, the β,γ-unsaturated keto sulfones could further react with 2,3-butadienoate to generate cyclopentenes in phosphine-mediated [3 + 2] cycloaddition.

Identifiers

PMID36545103

DOI10.1039/d2ra06784f

PMCPMC9745886

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LicenceCC BY-NC

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.