ArticleNeurobiology of stress2023
The influence of sleep on fear extinction in trauma-related disorders.
Article in Neurobiology of stress, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- At-home limbic-targeted transcranial electrical stimulation during sleep: a feasibility study in healthy adults.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026Article
- Slow Oscillation-Sleep Spindle Coupling Is Associated With Expectancy Measures of Fear Extinction Retention in Trauma-Exposed Individuals.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Dimensions of trauma: The relationship between daytime PTSD cluster symptomology and sleep measures.Psychological trauma : theory, research, practice and policy · 2026Article
- Neurobiological Signatures of Dyadic Transmission of Fear Extinction in Adolescent Trauma Exposure and Posttraumatic Stress.Biological psychiatry global open science · 2026Article
- Association of Sleep Quality, Sleep Disturbances, and Chronotype with Post-Traumatic Stress Disorder in Earthquake-Exposed Adolescents.Children (Basel, Switzerland) · 2026Article
- Key factors and serial mediation analysis of anxiety and depression among university students: a cross-sectional study.Frontiers in psychiatry · 2026Article
- Local and network neural activations and their associations with sleep parameters during threat conditioning and extinction in persons with Generalized Anxiety Disorder with and without Insomnia Disorder.bioRxiv : the preprint server for biology · 2025Article
- Review
- The Criticality of Consciousness: Excitatory-Inhibitory Balance and Dual Memory Systems in Active Inference.Entropy (Basel, Switzerland) · 2025Article
- Can Amygdala-Derived-EEG-fMRI-Pattern (EFP) Neurofeedback Treat Sleep Disturbances in PTSD?Brain sciences · 2025Article
- Slow oscillation-sleep spindle coupling is associated with fear extinction retention in trauma-exposed individuals.bioRxiv : the preprint server for biology · 2025Article
- Integrative approaches to studying sleep, stress, and related disorders.Neurobiology of stress · 2025Article
- REM disruption and REM Vagal Activity Predict Extinction Recall in Trauma-Exposed Individuals.bioRxiv : the preprint server for biology · 2024Article
- Insomnia, anxiety and related disorders: a systematic review on clinical and therapeutic perspective with potential mechanisms underlying their complex link.Neuroscience applied · 2024Review
- Targeting sleep quality in acutely traumatized individuals to reduce the risk for PTSD: study protocol for a multicentre randomized clinical trial.European journal of psychotraumatology · 2024Article
- Comparison of autonomic reactivity to trauma and nightmare imagery: A Pilot Study.Sleep advances : a journal of the Sleep Research Society · 2024Article
- Acute Stress Disorders Among Jordanian Adolescents After Watching Gaza News Footage on Social Media.Journal of multidisciplinary healthcare · 2024Article
- Understanding nightmares after traumatic events in Detroit (UNiTED): prospective associations with interpersonal violence and posttraumatic stress disorder symptoms.European journal of psychotraumatology · 2024Article
- Predicting Fear Extinction in Posttraumatic Stress Disorder.Brain sciences · 2023Article
- Neural pathways from hypothalamic orexin neurons to the ventrolateral preoptic area mediate sleep impairments induced by conditioned fear.Frontiers in neuroscience · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In Posttraumatic Stress Disorder (PTSD), fear and anxiety become dysregulated following psychologically traumatic events. Regulation of fear and anxiety involves both high-level cognitive processes such as cognitive reattribution and low-level, partially automatic memory processes such as fear extinction, safety learning and habituation. These latter processes are believed to be deficient in PTSD. While insomnia and nightmares are characteristic symptoms of existing PTSD, abundant recent evidence suggests that sleep disruption prior to and acute sleep disturbance following traumatic events both can predispose an individual to develop PTSD. Sleep promotes consolidation in multiple memory systems and is believed to also do so for low-level emotion-regulatory memory processes. Consequently sleep disruption may contribute to the etiology of PTSD by interfering with consolidation in low-level emotion-regulatory memory systems. During the first weeks following a traumatic event, when in the course of everyday life resilient individuals begin to acquire and consolidate these low-level emotion-regulatory memories, those who will develop PTSD symptoms may fail to do so. This deficit may, in part, result from alterations of sleep that interfere with their consolidation, such as REM fragmentation, that have also been found to presage later PTSD symptoms. Here, sleep disruption in PTSD as well as fear extinction, safety learning and habituation and their known alterations in PTSD are first briefly reviewed. Then neural processes that occur during the early post-trauma period that might impede low-level emotion regulatory processes through alterations of sleep quality and physiology will be considered. Lastly, recent neuroimaging evidence from a fear conditioning and extinction paradigm in patient groups and their controls will be considered along with one possible neural process that may contribute to a vulnerability to PTSD following trauma.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.