ArticleAlzheimer's & dementia (New York, N. Y.)2022
The reversible impairment of behavioral variant frontotemporal brain sagging syndrome: Challenges and opportunities.
Article in Alzheimer's & dementia (New York, N. Y.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06711731 (The Freiburg Registry on SpontanEous IntercrAnial Hypotension), which is not on this map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Freiburg Registry on SpontanEous IntercrAnial Hypotension (SIH) & Post-duraL Puncture Headache (PDPH)
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Endovascular embolization of cerebrospinal fluid-venous fistula: a comprehensive systematic review on its efficacy and safety for the management of spontaneous intracranial hypotension.Neurosurgical review · 2024Pooled it
- Symptomatic cerebral spinal fluid leak (or intracranial hypotension) due to sacral extradural cyst rupture after sacral fracture: illustrative case.Journal of neurosurgery. Case lessons · 2025Article
- Azygos Vein Stenosis in Frontotemporal Dementia Sagging Brain Syndrome.AJNR. American journal of neuroradiology · 2025Article
- Article
- Reply: Dementia in spontaneous intracranial hypotension: look at the spine.Neuroradiology · 2025Article
- Skull defect - Frontotemporal dementia sagging brain syndrome.Annals of clinical and translational neurology · 2025Article
- Spinal dementia: Don't miss it, it's treatable.Neuroradiology · 2024Article
- Compulsive Repetitive Flexion With Breath-Holding in Sagging Brain Syndrome.Neurology. Clinical practice · 2024Article
- Movement Disorders in Brain Sagging Syndrome Due To Spontaneous Intracranial Hypotension: A Review.Tremor and other hyperkinetic movements (New York, N.Y.) · 2024Review
- More than a headache-somatic and mental symptom burden in spontaneous intracranial hypotension before and after surgical treatment.Frontiers in neurology · 2024Article
- Brain Sagging Dementia.Current neurology and neuroscience reports · 2023Review
- The reversible impairment of behavioral variant frontotemporal brain sagging syndrome: Challenges and opportunities.Alzheimer's & dementia (New York, N. Y.) · 2022Article
- Could cerebrospinal fluid leak contribute to the link between traumatic brain injury and dementia?Alzheimer's & dementia (New York, N. Y.)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Due to loss of brain buoyancy, spontaneous spinal cerebrospinal fluid (CSF) leaks cause orthostatic headaches but also can cause symptoms indistinguishable from behavioral variant frontotemporal dementia (bvFTD) due to severe brain sagging (including the frontal and temporal lobes), as visualized on brain magnetic resonance imaging. However, the detection of these CSF leaks may require specialized spinal imaging techniques, such as digital subtraction myelography (DSM). Methods: We performed DSM in the lateral decubitus position under general anesthesia in 21 consecutive patients with frontotemporal dementia brain sagging syndrome (4 women and 17 men; mean age 56.2 years [range: 31-70 years]). Results: Nine patients (42.8%) were found to have a CSF-venous fistula, a recently discovered type of CSF leak that cannot be detected on conventional spinal imaging. All nine patients underwent uneventful surgical ligation of the fistula. Complete or near-complete and sustained resolution of bvFTD symptoms was obtained by all nine patients, accompanied by reversal of brain sagging, but in only three (25.0%) of the twelve patients in whom no CSF-venous fistula could be detected ( Discussion: Concerns about a spinal CSF leak should not be dismissed in patients with frontotemporal brain sagging syndrome, even when conventional spinal imaging is normal. However, even with this specialized imaging the source of the loss of spinal CSF remains elusive in more than half of patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.